Strophanthidin

Base Information

• Chemical Name: Strophanthidin
• CAS No.: 66-28-4
• Deprecated CAS: 11023-66-8,1398-86-3
• Molecular Formula: C23H32 O6
• Molecular Weight: 404.503
• European Community (EC) Number: 200-626-6
• NSC Number: 86078
• UNII: W5O632DN33
• DSSTox Substance ID: DTXSID00903966
• Nikkaji Number: J4.843G
• Wikipedia: K-Strophanthidin
• Wikidata: Q1718068
• Metabolomics Workbench ID: 35219
• ChEMBL ID: CHEMBL111743
• Mol file: 66-28-4.mol

Synonyms:Convallatoxigenin;Corchsularin;Cymarigenin;K Strophanthidin;K-Strophanthidin;KStrophanthidin;Strophanthidin

Chemical Property of Strophanthidin

Chemical Property:

• Vapor Pressure: 5.25E-18mmHg at 25°C
• Melting Point: 169°C
• Refractive Index: 1.4593 (estimate)
• Boiling Point: 620.7 °C at 760 mmHg
• PKA: 13.92±0.70(Predicted)
• Flash Point: 214.9 °C
• PSA: 104.06000
• Density: 1.432 g/cm³
• LogP: 1.89820
• Storage Temp.: −20°C
• Solubility.: ethanol: complete50mg/mL, clear, colorless to yellow
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 404.21988874
• Heavy Atom Count: 29
• Complexity: 777

Purity/Quality:

99% ^*data from raw suppliers

k-Strophanthidin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 26/27/28
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1(CCC2C4=CC(=O)OC4)O)CCC5(C3(CCC(C5)O)C=O)O
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@]1(CC[C@@H]2C4=CC(=O)OC4)O)CC[C@]5([C@@]3(CC[C@@H](C5)O)C=O)O
• Uses: Strophanthidin was used to synthesize acetylstrophanthidin and the effect on neurotransmitter release from dog saphenous vein was studied.3

Technology Process of Strophanthidin

There total 11 articles about Strophanthidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cymarin (508-77-0) → strophanthidin (66-28-4)

Guidance literature:

In propan-1-ol; at 140 ℃; for 5h;

DOI:10.1007/BF00629831

Reference yield:

→ strophanthidin (66-28-4)

Guidance literature:

With sulfuric acid; water;

Reference yield:

→ strophanthidin (66-28-4)

Guidance literature:

With hydrogenchloride; water; acetone;

upstream raw materials:

cymarin

neoconvalloside

gluco(1->6)olitoriside

Downstream raw materials:

convallatoxin

5,14-dihydroxy-3β-nicotinoyloxy-19-oxo-5β,14β-card-20(22)-enolide

3β-bromoacetoxy-5,14-dihydroxy-19-oxo-5β,14β-card-20(22)-enolide

pyridine

Refernces

• 1、 Nagata et al.. "-". . p. 41,60. Retrieved 1957.
• 2、 Makarevich, I. F.,Maslennikov, A. I.,Pavlii, A. I.,Kulagina, V. S.,Ol'khovik, D. V.,et al.. "THERMAL TRANSFORMATIONS OF CARDIAC GLYCOSIDES AND AGLYCONS". . p. 388 - 389. Retrieved 2007/10/02.
• 3、 Ricca, Giuliana Severini,Casagrande, Cesare. "13C-NMR SPECTRA OF STROPHANTIDIN GLYCOSIDES OF Corchorus capsularis L.; STRUCTURE OF A NEW GLYCOSIDE: GLUCO(1-->6)OLITORISIDE". . p. 349 - 352. Retrieved 2007/10/02.