3-Chloro-2-iodotoluene

Base Information

• Chemical Name: 3-Chloro-2-iodotoluene
• CAS No.: 5100-98-1
• Molecular Formula: C7H6ClI
• Molecular Weight: 252.482
• Hs Code.: 2903999090
• Mol file: 5100-98-1.mol

Synonyms:3-Chloro-2-iodotoluene;Toluene,3-chloro-2-iodo- (7CI,8CI);3-Chloro-2-iodotoluene,98%;

Chemical Property of 3-Chloro-2-iodotoluene

Chemical Property:

• Vapor Pressure: 0.0331mmHg at 25°C
• Melting Point: 25-27 °C
• Refractive Index: 1.616
• Boiling Point: 251.1 °C at 760 mmHg
• Flash Point: 105.7 °C
• PSA: 0.00000
• Density: 1.806 g/cm³
• LogP: 3.25300
• Storage Temp.: 2-8°C(protect from light)
• Sensitive.: Light Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-2-iodotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 36/38-50/53-41-37/38
• Safety Statements: 26-36/37/39-61-60-39

MSDS Files:

Useful:

Technology Process of 3-Chloro-2-iodotoluene

There total 4 articles about 3-Chloro-2-iodotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

2-chloro-6-methylaniline (87-63-8) → 1-chloro-2-iodo-3-methylbenzene (5100-98-1)

Guidance literature:

2-chloro-6-methylaniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 15 ℃; for 0.333333h; Large scale;

With potassium iodide; In water; ethyl acetate; at 0 - 10 ℃; for 1h; Temperature; Solvent; Large scale;

Reference yield:

2-iodo-3-nitrotoluene (6277-17-4) → 1-chloro-2-iodo-3-methylbenzene (5100-98-1)

Guidance literature:

Multi-step reaction with 2 steps

1: platinum; acetic acid / Hydrogenation

2: Diazotization_.Behandlung der Diazoniumsalz-Loesung mit CuCl in konz. wss. HCl

With acetic acid; platinum;

DOI:10.1021/ja01876a031

Reference yield:

2-iodo-1-methyl-3-methylaniline (89938-16-9) → 1-chloro-2-iodo-3-methylbenzene (5100-98-1)

Guidance literature:

Diazotization_.Behandlung der Diazoniumsalz-Loesung mit CuCl in konz. wss. HCl;

DOI:10.1021/ja01876a031

upstream raw materials:

2-iodo-1-methyl-3-methylaniline

2-chloro-6-methylaniline

2-iodo-3-nitrotoluene

Downstream raw materials:

2-chloro-6-methyl-benzonitrile

1-chloro-3-methylbenzene

methyl [2-(bromomethyl)-6-chlorophenyl]acetate

methyl (2-chloro-6-methylphenyl)acetate

Refernces

• 1、 -. "COMPOUNDS FOR TARGETED DEGRADATION OF BRD9". Page/Page column 351-352. . Retrieved 2021/09/11.
• 2、 -. "7 AND 8-Halo substituted 1,2,3,4-tetrahydroisoquinoline compounds". . . Retrieved 2008/06/13.