TILUDRONIC ACID, DISODIUM SALT

Base Information

• Chemical Name: TILUDRONIC ACID, DISODIUM SALT
• CAS No.: 149845-07-8
• Molecular Formula: C7H7ClNa2O6P2S
• Molecular Weight: 362.575
• Mol file: 149845-07-8.mol

Synonyms:Phosphonicacid, [[(4-chlorophenyl)thio]methylene]bis-, disodium salt (9CI);Disodiumtiludronate;SR 41319B;SR 41319G;Skelid;Tiludronate disodium;

Chemical Property of TILUDRONIC ACID, DISODIUM SALT

Chemical Property:

• Appearance/Colour: Fine White to Off-White Crystalline Powder
• Vapor Pressure: 2.79E-15mmHg at 25°C
• Melting Point: >300°C
• Boiling Point: 600.7 °C at 760 mmHg
• Flash Point: 317.1 °C
• PSA: 165.64000
• LogP: 2.94750
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tiludronic Acid, Disodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Tiludronate disodium, the first of the third generation of bisphosphonates, was introduced to the market in Switzerland for the treatment of Paget‘s disease. Bisphosphonates have high affinity for bone. When given orally, they are not metabolized but are absorbed, stored, preferentially localized to the skeleton where they inhibit bone resorption and therefore are useful in the treatment of diseases of high bone turnover such as Paget’s disease and hypercalcemia of malignancy. Mechanistically, tiludronate disodium is suggested to be a specific inhibitor of functioning osteoclasts through selective incorporation into the polarized osteoclastlike multinucleated cells and direct interference with the maintenance of the cytoskeletal structure. Tiludronate disodium is reportedly in clinical trials for osteoporosis in post-menopausal women.
• Uses: A biphosphonate bone resorption inhibitor.
• Therapeutic Function: Bone calcium regulator