ZG 63

Base Information

• Chemical Name: ZG 63
• CAS No.: 146137-59-9
• Molecular Formula: C₁₇H₁₈ClN₃O₃
• Molecular Weight: 347.801
• Mol file: 146137-59-9.mol

Synonyms:ZG 63

Chemical Property of ZG 63

Chemical Property:

• Vapor Pressure: 3.1E-12mmHg at 25°C
• Boiling Point: 552.1°Cat760mmHg
• Flash Point: 287.7°C
• PSA: 64.43000
• Density: 1.34g/cm³
• LogP: 3.00450

Purity/Quality:

99% ^*data from raw suppliers

ZG 63 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ZG 63

There total 2 articles about ZG 63 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-7-chloro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione (5973-29-5) → tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate (146137-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, DMF, 20 min, 2.) THF, DMF, 30 min

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, THF, a.) 30 min, b.) RT, overnight

With sodium hydride;

DOI:10.1021/jm00060a007

Reference yield:

tert-butyl isocyanoacetate + Phosphoric acid 7-chloro-4-methyl-5-oxo-4,5-dihydro-1H-benzo[e][1,4]diazepin-2-yl ester diethyl ester → tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate (146137-59-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 15 min, 2.) DMF, THF, a.) 30 min, b.) RT, overnight;

DOI:10.1021/jm00060a007

upstream raw materials:

3,4-dihydro-7-chloro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione

Refernces