Tebipenem pivoxil

Base Information Edit

Chemical Name:Tebipenem pivoxil
CAS No.:161715-24-8
Molecular Formula:C₂₂H₃₁N₃O₆S₂
Molecular Weight:497.637
Hs Code.:
UNII:95AK1A52I8
DSSTox Substance ID:DTXSID00167228
Nikkaji Number:J1.972.377A
Wikidata:Q1623593
NCI Thesaurus Code:C76566
ChEMBL ID:CHEMBL2107486
Mol file:161715-24-8.mol

Synonyms:L 084;L-084;tebipenem pivoxil

Suppliers and Price of Tebipenem pivoxil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TebipenemPivoxil
100mg
$ 1210.00

Medical Isotopes, Inc.
TebipenemPivoxil
100 mg
$ 2000.00

Medical Isotopes, Inc.
TebipenemPivoxil
10 mg
$ 625.00

Labseeker
(1R,5S,6S)-6-[1(R)-Hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl]-1-carba-2-penem-3-carboxylicaci 98
10g
$ 500.00

DC Chemicals
Tebipenempivoxil(L-084) >99%
100 mg
$ 275.00

DC Chemicals
Tebipenempivoxil(L-084) >99%
250 mg
$ 550.00

DC Chemicals
Tebipenempivoxil(L-084) >99%
1 g
$ 1100.00

Crysdot
Tebipenempivoxil 98+%
100mg
$ 1015.00

Crysdot
Tebipenempivoxil 98+%
25mg
$ 281.00

Crysdot
Tebipenempivoxil 98+%
50mg
$ 535.00

Total 133 raw suppliers

Chemical Property of Tebipenem pivoxil Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:140-142℃
Refractive Index:1.688
Boiling Point:661.905 °C at 760 mmHg
PKA:14.36±0.20(Predicted)
Flash Point:354.107 °C
PSA：159.34000
Density:1.504 g/cm³
LogP:0.97710
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:10
Exact Mass:497.16542806
Heavy Atom Count:33
Complexity:908

Purity/Quality:

99%min ^*data from raw suppliers

TebipenemPivoxil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)C(C)O
Isomeric SMILES:C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)[C@@H](C)O
Recent ClinicalTrials:Tebipenem Trial in Children With Shigellosis
Recent EU Clinical Trials:A Phase 3, Randomized, Double-blind, Double-dummy, Multicenter, Prospective Study to Assess the Efficacy, Safety and Pharmacokinetics of Orally Administered Tebipenem Pivoxil Hydrobromide (SPR994) Compared to Intravenous Ertapenem in Patients with Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP)
Recent NIPH Clinical Trials:Clinical evaluation of tebipenem pivoxil in the treatment of child community-acquired bacterial pneumonia
Uses Tebipenem Pivoxil is an oral carbapenem antibiotic. Tebipenem Pivoxil is absorbed and metabolized into Tebipenem, its active metabolite which showed excellent bactericidal activity against β-lactamase -nonproducing, ampicillin-resistant isolates. Tebipenem Pivoxil is an oral carbapenem antibiotic. Tebipenem Pivoxil is absorbed and metabolized into Tebipenem, its active metabolite which showed excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates. Tebipenem pivoxil(L-084) is a novel oral carbapenem antibiotic with an IC50 of 100 μg/ml for human CYP isoforms. In mouse, rat, dog and monkey, TBPM-PI were absorbed quickly, and the bioavailability was (71.4, 59.1, 34.8 and 44.9%, respectively. There was

Technology Process of Tebipenem pivoxil

There total 21 articles about Tebipenem pivoxil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%

: C₂₈H₃₂NO₉P

: C₁₂H₁₈N₄S₃

: 161715-24-8
tebipenem

Guidance literature:: C₁₂H₁₈N₄S₃; With tributylphosphine; In water; acetonitrile; at 20 - 35 ℃; for 0.833333h; Inert atmosphere;

C₂₈H₃₂NO₉P; With N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at -10 - 35 ℃; for 4h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;