Metamfepramone

Base Information

• Chemical Name: Metamfepramone
• CAS No.: 15351-09-4
• Molecular Formula: C11H15 N O
• Molecular Weight: 177.246
• Hs Code.: 2922399090
• European Community (EC) Number: 239-384-1
• NSC Number: 234706
• UNII: 04A0P12FH2
• DSSTox Substance ID: DTXSID7057650
• Nikkaji Number: J8.560J
• Wikipedia: Metamfepramone
• Wikidata: Q6822988
• NCI Thesaurus Code: C83947
• Metabolomics Workbench ID: 155771
• ChEMBL ID: CHEMBL2105245
• Mol file: 15351-09-4.mol

Synonyms:2-(dimethylamino)propiophenone;dimepropion;dimethylpropion;metamfepramone

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Chemical Property of Metamfepramone

Chemical Property:

• Vapor Pressure: 0.0152mmHg at 25°C
• Refractive Index: 1.5480 (estimate)
• Boiling Point: 256.6°C at 760 mmHg
• PKA: 7.39±0.50(Predicted)
• Flash Point: 84.9°C
• PSA: 20.31000
• Density: 0.995g/cm³
• LogP: 1.81940
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1)N(C)C

Technology Process of Metamfepramone

There total 14 articles about Metamfepramone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-dimethylamino-1-phenyl-propan-1-ol (17605-71-9) → metamfepramone (15351-09-4)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; for 48h; Ambient temperature;

DOI:10.1021/jo00127a036

Reference yield: 91.0%

2-chloro-1-phenylpropan-1-one (6084-17-9) + dimethyl amine (124-40-3) → metamfepramone (15351-09-4)

Guidance literature:

In benzene; for 96h; Ambient temperature;

Reference yield: 89.0%

2-bromo-1-phenyl-1-propanone (2114-00-3) + dimethyl amine (124-40-3) → metamfepramone (15351-09-4)

Guidance literature:

In benzene; 1.) 0 deg C, 30 min, 2.) 2 d;

upstream raw materials:

2-(dimethylamino)-propionic acid N,N-dimethylamide

(+/-)-cathinone

2-bromo-1-phenyl-1-propanone

dimethyl amine

Downstream raw materials:

2-dimethylamino-3-phenyl-pentan-3-ol

2-dimethylamino-1,1-diphenyl-propan-1-ol

3-dimethylamino-1-(4-methoxy-phenyl)-2-phenyl-butan-2-ol

1-cyclohexyl-2-dimethylamino-1-phenyl-propan-1-ol

Refernces

• 1、 Shinde, Mahesh H.,Kshirsagar, Umesh A.. "N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes". supporting information. p. 858 - 861. Retrieved 2016/01/15.
• 2、 Shindo, Mitsuru,Yoshikawa, Takashi,Itou, Yasuaki,Mori, Seiji,Nishii, Takeshi,Shishido, Kozo. "Heteroatom-guided torquoselective olefination of α-oxy and α-amino ketones via ynolates". . p. 524 - 536. Retrieved 2008/09/20.