2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid

Base Information

• Chemical Name: 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid
• CAS No.: 1384949-92-1
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 1384949-92-1.mol

Synonyms:2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid

Chemical Property of 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid

There total 2 articles about 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

chloroform (67-66-3,8013-54-5) + 2-isopropenyl-4-methylphenol (65490-14-4) + acetone (67-64-1) → 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid (1384949-92-1)

Guidance literature:

chloroform; 2-isopropenyl-4-methylphenol; acetone; With sodium hydroxide; for 5h; Reflux; Inert atmosphere;

With hydrogenchloride; In chloroform; water; Cooling;

DOI:10.1016/j.tet.2012.05.041

Reference yield:

4,6-dimethyl-chromen-2-one (14002-89-2) → 2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid (1384949-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethylene glycol / 2 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / 5 h / Reflux; Inert atmosphere

2.2: Cooling

With potassium hydroxide; sodium hydroxide; In ethylene glycol; 2.1: Bargellini reaction;

DOI:10.1016/j.tet.2012.05.041

Reference yield: 86.0%

2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid (1384949-92-1) → 2-methyl-2-(4-methyl-2-isoprenyl-phenoxy)-propan-1-ol (1384949-94-3)

Guidance literature:

2-(2-isopropenyl-4-methyl-phenoxy)-2-methyl-propionic acid; With lithium aluminium tetrahydride; In diethyl ether; for 4h; Inert atmosphere; Reflux;

With water; sodium sulfate; In diethyl ether; Saturated solution; Cooling;

DOI:10.1016/j.tet.2012.05.041

upstream raw materials:

4,6-dimethyl-chromen-2-one

chloroform

2-isopropenyl-4-methylphenol

acetone

Downstream raw materials:

2-methyl-2-(4-methyl-2-isoprenyl-phenoxy)-propan-1-ol

Refernces