Technology Process of 4-Amino-1-((4aR,7S,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-1H-pyrimidin-2-one
There total 12 articles about 4-Amino-1-((4aR,7S,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-1H-pyrimidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
dimethyl sulfoxide;
at 50 ℃;
DOI:10.1021/jm00066a013
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) dibutyltin oxide / 1.) benzene, reflux, 16 h, 2.) dioxane, RT, 5 h
2: 4-(dimethylamino)pyridine (DMAP) / CH2Cl2 / 1 h / Ambient temperature
3: CH2Cl2 / 2 h / Ambient temperature
4: tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 80 °C
5: 80 percent / NaOMe / methanol / 4 h / Ambient temperature
6: 37 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD) / tetrahydrofuran; dioxane / 15 h / Ambient temperature
7: 400 mg / NH3 / methanol / 5 h / Ambient temperature
With
dmap; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; sodium methylate; di(n-butyl)tin oxide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jm00066a013
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaOMe / 2 h / Ambient temperature
2: ZnCl2 / 48 h / Ambient temperature
3: 1.) dibutyltin oxide / 1.) benzene, reflux, 16 h, 2.) dioxane, RT, 5 h
4: 4-(dimethylamino)pyridine (DMAP) / CH2Cl2 / 1 h / Ambient temperature
5: CH2Cl2 / 2 h / Ambient temperature
6: tri-n-butyltin hydride, 2,2'-azobis(2-methylpropionitrile) / toluene / 80 °C
7: 80 percent / NaOMe / methanol / 4 h / Ambient temperature
8: 37 percent / triphenylphosphine, diethyl azodicarboxylate (DEAD) / tetrahydrofuran; dioxane / 15 h / Ambient temperature
9: 400 mg / NH3 / methanol / 5 h / Ambient temperature
With
dmap; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; sodium methylate; di(n-butyl)tin oxide; triphenylphosphine; zinc(II) chloride; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jm00066a013