CID 9868292

Base Information

• Chemical Name: CID 9868292
• CAS No.: 81131-70-6
• Molecular Formula: C₂₃H₃₅O₇*Na
• Molecular Weight: 446.516
• Hs Code.: 29329990
• NCI Thesaurus Code: C29375
• RXCUI: 203144
• Mol file: 81131-70-6.mol

Synonyms:Apo Pravastatin;Apo-Pravastatin;Bristacol;CS 514;CS-514;CS514;Elisor;Eptastatin;Lin Pravastatin;Lin-Pravastatin;Lipemol;Liplat;Lipostat;Mevalotin;Nu Pravastatin;Nu-Pravastatin;Prareduct;Pravachol;Pravacol;Pravasin;Pravastatin;Pravastatin Monosodium Salt, (6 beta)-Isomer;Pravastatin Sodium;Pravastatin Sodium Salt;Pravastatin tert Octylamine Salt;Pravastatin tert-Octylamine Salt;Pravastatin, (6 beta)-Isomer;RMS 431;RMS-431;RMS431;Selektine;Sodium Salt, Pravastatin;SQ 31,000;SQ 31000;SQ-31,000;SQ-31000;SQ31,000;SQ31000;Vasten

Chemical Property of CID 9868292

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 171.2-173 °C
• Boiling Point: 634.5 °C at 760 mmHg
• Flash Point: 213.2 °C
• PSA: 124.29000
• LogP: 2.55290
• Storage Temp.: 2-8°C
• Solubility.: H2O: 19 mg/mL
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 11
• Exact Mass: 447.23587277
• Heavy Atom Count: 31
• Complexity: 656

Purity/Quality:

99%, ^*data from raw suppliers

Pravastatin Sodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O.[Na]
• Isomeric SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O.[Na]
• Recent ClinicalTrials: S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia
• Recent EU Clinical Trials: A feasibility study investigating pravastatin for the prevention of preterm birth in women
• Recent NIPH Clinical Trials: Evaluation of the effect of Angiotensin ll receptor blocker for plaque vulnerability after percutaneous coronary intervention (PCI)
• Uses: A competitive inhibitor of HMG-CoA reductase. Bioactive metabolite of Mevastatin Pravastatin sodium is the salt of pravastatin, a ring-opened member of the statin family. Pravastatin is produced biosynthetically from compactin (mevastatin) by a number of microorganisms, notably Absidia, Cunninghamella, Syncephalastrum, Nocardia or Streptomyces. Typically, statins like compactin, lovastatin and simvastatin possess a β-hydroxy lactone ring which is a pro-drug for the readily ring-opened dihydroxyacid generally regarded as the active HMG-CoAreductase inhibitor. Importantly, the free carboxylic acid enables pravastatin to be freely water soluble within biological pH ranges. An HMGCR inhibitor which blocks cholesterol synthesis
• Therapeutic Function: Antihyperlipidemic
• Clinical Use: HMG CoA reductase inhibitor: Hypercholesterolaemia
• Drug interactions: Potentially hazardous interactions with other drugs Antibacterials: increased risk of myopathy with daptomycin, fusidic acid (avoid) and telithromycin; concentration increased by clarithromycin and erythromycin. Antivirals: increased risk of myopathy with atazanavir and boceprevir; concentration possibly increased by darunavir; concentration reduced by efavirenz. Ciclosporin: increased risk of myopathy. Colchicine: possible increased risk of myopathy. Lipid lowering agents: increased risk of myopathy with fibrates, gemfibrozil (avoid) and nicotinic acid.

Technology Process of CID 9868292

There total 8 articles about CID 9868292 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pravastatin (81093-37-0,81131-74-0,250737-12-3) → pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

With sodium carbonate; In acetic acid butyl ester; for 3h; Product distribution / selectivity;

Reference yield: 68.4%

→ pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

Reference yield:

t-octylamine salt of pravastatin → pravastatin sodium salt (81131-70-6,81176-41-2,124917-23-3)

Guidance literature:

t-octylamine salt of pravastatin; With sodium hydroxide; In acetic acid butyl ester; water; for 0.166667h; pH=11.3;

In water; pH=8.2;

upstream raw materials:

pravastatin

mevastatin

3β-hydroxy ML-236B methylester

3β-hydroxy ML-236B

Downstream raw materials:

pravastatin lactone

R-195

pravastatin

lactone form of C-6 epimer of pravastatin

Refernces

• 1、 -. "Methods for predicting the response to statins". . . Retrieved 2011/10/13.
• 2、 -. "PROCESS FOR THE PREPARATION OF 1,2,6,7,8,8A-HEXAHYDRO-BETA,DELTA,6-TRIHYDROXY-2-METHYL-8-[(2S)-2-METHYL-1-OXOBUTOXY]-, (BETA R,DELTA R,1S,2S,6S,8S,8AR)-1-NAPHTHALENEHEPTANOIC ACID, SODIUM SALT.". Page/Page column 8. . Retrieved 2008/06/13.