Technology Process of C22H21FN2O3
There total 7 articles about C22H21FN2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C18H12FNO2; L-alanine methyl ester hydrochloride;
With
sodium tris(acetoxy)borohydride; triethylamine;
In
1,2-dichloro-ethane;
at 20 ℃;
for 15h;
Inert atmosphere;
With
water; sodium hydrogencarbonate;
In
ethyl acetate; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere
6.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15 h / 20 °C / Inert atmosphere
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / Inert atmosphere
3.1: sulfuric acid / 1,2-dimethoxyethane; water
3.2: 0.83 h / 0 - 5 °C
3.3: 0.5 h / 0 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 18 h / 90 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 20 h / 60 °C / Inert atmosphere
6.1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15 h / 20 °C / Inert atmosphere
With
sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; 5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;