Carbasalate calcium

Base Information

• Chemical Name: Carbasalate calcium
• CAS No.: 5749-67-7
• Molecular Formula: CH₄N₂O*2C₉H₇O₄*Ca
• Molecular Weight: 458.438
• Mol file: 5749-67-7.mol

Synonyms:Carbasalate calcique [INN-French];Calcium carbaspirin;calcium; 2-acetyloxybenzoate; urea;Calcium acetylsalicylate complex with urea;2-acetyloxybenzoic acid; urea;Calcium acetylsalicylic carbamidate;Carbasalato calcico [INN-Spanish];Salicylic acid acetate calcium salt, compound with urea (1:1) complex;Carbasalatum calcicum [INN-Latin];Carbaspirin calcium [USAN];Calcium carbasalate;Benzoic acid, 2-(acetyloxy)-, calcium salt, compd. with urea (1:1);Carbasalate Calcium;Carbasalate Calcium EP5;

Chemical Property of Carbasalate calcium

Chemical Property:

• Appearance/Colour: White or almost white crystalline powder
• Boiling Point: 321.4 °C at 760 mmHg
• Flash Point: 131.2 °C
• PSA: 174.31000
• LogP: 2.89040
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Freely soluble in water and in dimethylformamide, practically insoluble in acetone and in anhydrous methanol.

Purity/Quality:

99% ^*data from raw suppliers

Carbasalatecalcium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Carbasalate Calcium is an analgesic, antipyretic, and anti-inflammatory drug. Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; antiinflammatory.
• Description: Carbasalate calcium is a calcium-urea chelate of aspirin that has analgesic, anti-inflammatory, and antipyretic effects. It reduces carrageenan-induced paw edema in rats.

Technology Process of Carbasalate calcium

There total 1 articles about Carbasalate calcium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

calcium O-acetylsalicylate (69-46-5) + urea (57-13-6) → bis(2-acetoxybenzoic acid) calcium urea (3063-60-3,5749-67-7)

Guidance literature:

In water; for 0.0833333h; Industrial scale;

Reference yield:

bis(2-acetoxybenzoic acid) calcium urea (3063-60-3,5749-67-7) → salicylic acid (69-72-7,25496-36-0,8052-31-1)

Guidance literature:

bis(2-acetoxybenzoic acid) calcium urea; With sulfuric acid; In water; at 20 ℃; pH=1 - 2; Large scale;

With sodium carbonate; In water; at 90 - 95 ℃; for 0.666667h; pH=8; pH-value; Large scale;

upstream raw materials:

calcium O-acetylsalicylate

urea

Downstream raw materials:

salicylic acid

Refernces