ALPHA-CHLORO-2-NITROACETANILIDE

Base Information

• Chemical Name: ALPHA-CHLORO-2-NITROACETANILIDE
• CAS No.: 10147-70-3
• Molecular Formula: C8H7ClN2O3
• Molecular Weight: 214.608
• Hs Code.: 2924299090
• Mol file: 10147-70-3.mol

Synonyms:Acetanilide,2-chloro-2'-nitro- (6CI,7CI,8CI);2-Chloro-2'-nitroacetanilide;2-Chloro-N-(2-nitrophenyl)acetamide;N-(2-Nitrophenyl)chloroacetamide;N-Chloroacetyl-2-nitroaniline;NSC 8365;

Chemical Property of ALPHA-CHLORO-2-NITROACETANILIDE

Chemical Property:

• Vapor Pressure: 3.01E-07mmHg at 25°C
• Melting Point: 91-92 °C
• Refractive Index: 1.63
• Boiling Point: 419.5 °C at 760 mmHg
• PKA: 11.61±0.70(Predicted)
• Flash Point: 207.5 °C
• PSA: 74.92000
• Density: 1.472 g/cm³
• LogP: 2.36830

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-N-(2-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-CHLORO-2-NITROACETANILIDE

There total 10 articles about ALPHA-CHLORO-2-NITROACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-nitro-aniline (88-74-4) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-nitrophenyl)acetamide (10147-70-3)

Guidance literature:

In N,N-dimethyl-formamide; for 1.5h; Cooling with ice;

DOI:10.1007/s11172-009-0167-3

Reference yield: 94.0%

2-nitro-aniline (88-74-4) → 2-chloro-N-(2-nitrophenyl)acetamide (10147-70-3)

Guidance literature:

Reference yield: 94.0%

→ 2-chloro-N-(2-nitrophenyl)acetamide (10147-70-3)

Guidance literature:

upstream raw materials:

2-nitro-aniline

chloroacetyl chloride

N-chloroacetyl-aniline

nitric acid

Downstream raw materials:

4-{[(2-nitro-phenylcarbamoyl)-methyl]-amino}-benzoic acid ethyl ester

S-{2-[(2-nitrophenyl)amino]-2-oxoethyl}ethanethioate

N-(2-nitrophenyl)-2-(2,6-cis-dimethylmorpholino)acetamide

2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-(2-nitrophenyl)acetamide

Refernces

• 1、 Valiveti, Aditya Kapil,Bhalerao, Uma M.,Acharya, Jyotiranjan,Karade, Hitendra N.,Gundapu, Raviraju,Halve, Anand K.,Kaushik, Mahabir Parshad. "Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE)". . p. 125 - 132. Retrieved 2015.
• 2、 Modh, Rahul P.,Kumar, Sivakumar Prasanth,Jasrai, Yogesh T.,Chikhalia, Kishor H.. "Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors". . p. 793 - 804. Retrieved 2013.
• 3、 Deshmukh, Tejshri R.,Khare, Smita P.,Khedkar, Vijay M.,Krishna, Vagolu S.,Sangshetti, Jaiprakash N.,Shingate, Bapurao B.,Sriram, Dharmarajan. "Synthesis, bioevaluation and molecular docking study of new piperazine and amide linked dimeric 1,2,3-triazoles". . . Retrieved 2019.
• 4、 Sepehri, Nima,Azizian, Homa,Ghadimi, Reza,Abedinifar, Fahimeh,Mojtabavi, Somayeh,Faramarzi, Mohammad Ali,Moghadamnia, Ali Akbar,Zabihi, Ebrahim,Mohebbi, Gholamhossein,Larijani, Bagher,Hamedifar, Haleh,Mohammadi-Khanaposhtani, Maryam,Mahdavi, Mohammad. "New 4,5-diphenylimidazole-acetamide-1,2,3-triazole hybrids as potent α-glucosidase inhibitors: synthesis, in vitro and in silico enzymatic and toxicity evaluations". . p. 679 - 693. Retrieved 2021.
• 5、 Hosseini, Samanesadat,Mahdavi, Mohammad,Pourmousavi, Seied Ali,Taslimi, Parham. "Synthesis, and in vitro biological evaluations of novel naphthoquinone conjugated to aryl triazole acetamide derivatives as potential anti-Alzheimer agents". . . Retrieved 2022/01/26.
• 6、 Yavari, Ali,Mohammadi-Khanaposhtani, Maryam,Moradi, Shahram,Bahadorikhalili, Saeed,Pourbagher, Roghayeh,Jafari, Nasrin,Faramarzi, Mohammad Ali,Zabihi, Ebrahim,Mahdavi, Mohammad,Biglar, Mahmood,Larijani, Bagher,Hamedifar, Haleh,Hajimiri, Mir Hamed. "α-Glucosidase and α-amylase inhibition, molecular modeling and pharmacokinetic studies of new quinazolinone-1,2,3-triazole-acetamide derivatives". . p. 702 - 711. Retrieved 2021/01/18.