3-Ethoxy-5-methyl-1H-pyrazole

Base Information

• Chemical Name: 3-Ethoxy-5-methyl-1H-pyrazole
• CAS No.: 3201-21-6
• Molecular Formula: C6H10 N2 O
• Molecular Weight: 126.158
• Hs Code.: 2933199090
• Mol file: 3201-21-6.mol

Synonyms:Pyrazole,3(or 5)-ethoxy-5(or 3)-methyl- (6CI,7CI); Pyrazole, 3-ethoxy-5-methyl- (8CI);3-Ethoxy-5-methyl-1H-pyrazole; 3-Ethoxy-5-methylpyrazole;3-Methyl-5-ethoxypyrazole; 5-Ethoxy-3-methylpyrazole; NSC 243820

Chemical Property of 3-Ethoxy-5-methyl-1H-pyrazole

Chemical Property:

• Vapor Pressure: 0.02mmHg at 25°C
• Melting Point: 66-67 °C
• Boiling Point: 260.3°C at 760 mmHg
• PKA: 13.76±0.10(Predicted)
• Flash Point: 95.3°C
• PSA: 37.91000
• Density: 1.071g/cm³
• LogP: 1.11680

Purity/Quality:

99% ^*data from raw suppliers

3-Ethoxy-5-methyl-1H-pyrazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethoxy-5-methyl-1H-pyrazole

There total 3 articles about 3-Ethoxy-5-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl acetoacetate (141-97-9) → 3-ethoxy-5-methyl-1H-pyrazole (3201-21-6)

Guidance literature:

With bis(L-prolinato-N,O)zinc(II); hydrazine hydrate; In water; at 20 ℃; for 6h;

DOI:10.1016/j.jorganchem.2010.09.012

Reference yield: 62.0%

3-hydroxybut-2-enethioate de O-ethyle (110921-59-0) → 3-ethoxy-5-methyl-1H-pyrazole (3201-21-6)

Guidance literature:

With hydrazine hydrate; triethylamine; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1246/bcsj.73.1861

Reference yield:

→ 3-ethoxy-5-methyl-1H-pyrazole (3201-21-6)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethyl acetoacetate

3-hydroxybut-2-enethioate de O-ethyle

Downstream raw materials:

3-methyl-2-pyrazoline-5-one

5-ethoxy-3-methyl-pyrazole-1-carboxylic acid anilide

Refernces

• 1、 Liu, Yuanyuan,He, Guangke,Chen, Kai,Jin, Yin,Li, Yufeng,Zhu, Hongjun. "DMF-catalyzed direct and regioselective C-H functionalization: Electrophilic/nucleophilic 4-halogenation of 3-oxypyrazoles". supporting information; experimental part. p. 5323 - 5330. Retrieved 2011/11/13.
• 2、 Guillou, Sandrine,Bonhomme, Frederic J.,Janin, Yves L.. "An improved preparation of 3-alkoxypyrazoles". experimental part. p. 3504 - 3508. Retrieved 2009/05/09.