Glyceric acid 1,3-biphosphate

Base Information

• Chemical Name: Glyceric acid 1,3-biphosphate
• CAS No.: 1981-49-3
• Molecular Formula: C₃H₈O₁₀P₂
• Molecular Weight: 266.038
• DSSTox Substance ID: DTXSID50941636
• Wikipedia: 1,3-Bisphosphoglyceric_acid
• Wikidata: Q1020557
• Metabolomics Workbench ID: 126754
• ChEMBL ID: CHEMBL2074701
• Mol file: 1981-49-3.mol

Synonyms:1,3-biphosphoglycerate;1,3-biphosphoglyceric acid;1,3-bisphosphoglycerate;1,3-diphosphoglycerate;3-phosphoglyceroyl phosphate;glycerate 1,3-biphosphate

Chemical Property of Glyceric acid 1,3-biphosphate

Chemical Property:

• Vapor Pressure: 5.32E-19mmHg at 25°C
• Boiling Point: 638.7°Cat760mmHg
• PKA: 1.36±0.10(Predicted)
• Flash Point: 340°C
• PSA: 190.44000
• Density: 2.143g/cm³
• LogP: -1.90750
• XLogP3: -3.9
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 6
• Exact Mass: 265.95927044
• Heavy Atom Count: 15
• Complexity: 311

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(=O)OP(=O)(O)O)O)OP(=O)(O)O
• Uses: Phosphono 2-hydroxy-3- phosphonooxypropanoate is a biological metabolite of glucose and can be involved in oncogenesis.

Technology Process of Glyceric acid 1,3-biphosphate

There total 22 articles about Glyceric acid 1,3-biphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phosphoglyceric acid (820-11-1,3443-58-1,73358-94-8,111614-09-6) + ATP (56-65-5,896506-78-8) → glyceric acid 1,3-biphosphate (38168-82-0,1981-49-3) + adenosine 5'-diphosphate (58-64-0,905904-58-7)

Guidance literature:

With human phosphoglycerate kinase; magnesium chloride; diothiothreitol; In various solvent(s); at 25 ℃; pH=7.5; Enzyme kinetics;

DOI:10.1016/j.bcp.2004.06.012

Reference yield:

DL-glyceraldehyde 3-phosphate (142-10-9,591-57-1,20283-52-7,591-59-3) → glyceric acid 1,3-biphosphate (38168-82-0,1981-49-3)

Guidance literature:

With dipotassium hydrogenphosphate; NAD; glyceraldehyde-3-phosphate dehydrogenase; In various solvent(s); at 25 ℃; for 0.2h; pH=7.5;

DOI:10.1016/j.bcp.2004.06.012

Reference yield:

D-glyceraldehyde-3-phosphate (591-57-1) → glyceric acid 1,3-biphosphate (38168-82-0,1981-49-3)

Guidance literature:

With aldehyde dehydrogenase from Bacillus stearothermophilus; C₂₂H₂₈N₇O₁₆P₃^(4-); In aq. buffer; at 30 ℃; pH=8; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1002/anie.202017027

upstream raw materials:

L-ATP

3-phosphoglyceric acid

β-L-GTP

DL-glyceraldehyde 3-phosphate

Downstream raw materials:

3-phosphoglyceric acid

ATP

Refernces

• 1、 D?ring, Manuel,Sieber, Volker,Simon, Robert C.,Tafertshofer, Georg,Zachos, Ioannis. "carba Nicotinamide Adenine Dinucleotide Phosphate: Robust Cofactor for Redox Biocatalysis". supporting information. p. 14701 - 14706. Retrieved 2021/05/13.
• 2、 Gallois-Montbrun, Sarah,Faraj, Abdesslem,Seclaman, Edward,Sommadossi, Jean-Pierre,Deville-Bonne, Dominique,Véron, Michel. "Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs". . p. 1749 - 1756. Retrieved 2007/10/03.