(S)-Norfenfluramine

Base Information

• Chemical Name: (S)-Norfenfluramine
• CAS No.: 19036-73-8
• Molecular Formula: C10H12 F3 N
• Molecular Weight: 203.207
• Hs Code.: 2921499090
• European Community (EC) Number: 242-769-7
• UNII: CLX07A6ZIY
• Nikkaji Number: J93.839D
• Wikidata: Q27088005
• Pharos Ligand ID: B5JXB7VBLRXN
• ChEMBL ID: CHEMBL253811
• Mol file: 19036-73-8.mol

Synonyms:Dexnorfenfluramine;Nordexfenfluramine;Norfenfluramine

Chemical Property of (S)-Norfenfluramine

Chemical Property:

• Boiling Point: 215.2°Cat760mmHg
• Flash Point: 88.9°C
• PSA: 26.02000
• Density: 1.152g/cm³
• LogP: 3.29540
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 203.09218387
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98% ^*data from raw suppliers

(2S)-1-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-YLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=CC=C1)C(F)(F)F)N
• Isomeric SMILES: C[C@@H](CC1=CC(=CC=C1)C(F)(F)F)N

Technology Process of (S)-Norfenfluramine

There total 8 articles about (S)-Norfenfluramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(S)-N-((S)-1-phenylethyl)-1-(3-(trifluoromethyl)phenyl)propan-2-amine (213202-12-1) → (S)-norfenfluramine (19036-73-8)

Guidance literature:

With sodium hydroxide; palladium; In methanol; water;

Reference yield: 92.0%

(S)-N-((S)-1-phenylethyl)-1-(3-(trifluoromethyl)phenyl)propan-2-amine (213202-12-1) + palladium (7440-05-3) → (S)-norfenfluramine (19036-73-8)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield:

(S),(S)-N-(1-phenylethyl)-α-methyl-3-(trifluoromethyl)benzeneethanamine (58225-71-1) → (S)-norfenfluramine (19036-73-8)

Guidance literature:

With hydrogenchloride; sodium hydroxide; palladium; In methanol; water; toluene;

upstream raw materials:

2-[(S)-1-Methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-isoindole-1,3-dione

3-(trifluoromethyl)phenylacetone

1-[(3′-trifluoromethyl)phenyl]-2-propanol

(R)-1-(3’-trifluoromethylphenyl)-2-propanol

Refernces

• 1、 Fogagnolo, Marco,Giovannini, Pier Paolo,Guerrini, Alessandra,Medici, Alessandro,Pedrini, Paola,Colombi, Nicola. "Homochiral (R)- and (S)-1-heteroaryl- and 1-aryl-2-propanols via microbial redox". . p. 2317 - 2327. Retrieved 2007/10/03.
• 2、 -. "Process for the production of the isomers (R) and (S)-Alpha-methyl-3-(trifluoromethyl)benzeneethanamine". . . Retrieved 2008/06/13.