Technology Process of 3,3-bis(ethoxycarbonyl)-2-methylene<4-13C>-γ-butyrolactone
There total 1 articles about 3,3-bis(ethoxycarbonyl)-2-methylene<4-13C>-γ-butyrolactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; potassium hydrogencarbonate;
at 45 ℃;
for 48h;
Yield given;
DOI:10.1039/P29880000061
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 86 percent / 20 percent HCl / 1.) 45 deg C, 16 h; 2.) 45 deg C, 16 h
2: 85 percent / 50 percent NaH / tetrahydrofuran; paraffin / 1.) 1 h, 45 deg C; 2.) 45 deg C, 24 h; 3.) RT, 24 h
With
hydrogenchloride; sodium hydride;
In
tetrahydrofuran; paraffin;
DOI:10.1039/P29880000061
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 86 percent / 20 percent HCl / 1.) 45 deg C, 16 h; 2.) 45 deg C, 16 h
2: 85 percent / 50 percent NaH / tetrahydrofuran; paraffin / 1.) 1 h, 45 deg C; 2.) 45 deg C, 24 h; 3.) RT, 24 h
3: 88 percent / 50 percent NaH, hexamethylphosphoramide, NaOH / paraffin; tetrahydrofuran / 1.) 60 deg C, 1 h; 2.) 60 deg C, 13.5 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium hydride;
In
tetrahydrofuran; paraffin;
DOI:10.1039/P29880000061
