5-METHYL-IMIDAZO[1,2-A]PYRIDINE

Base Information

• Chemical Name: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE
• CAS No.: 933-69-7
• Molecular Formula: C8H8 N2
• Molecular Weight: 132.16
• Hs Code.: 2933990090
• Mol file: 933-69-7.mol

Synonyms:NSC 305205

Chemical Property of 5-METHYL-IMIDAZO[1,2-A]PYRIDINE

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 7.44±0.50(Predicted)
• Flash Point: °C
• PSA: 17.30000
• Density: 1.11g/cm³
• LogP: 1.64270

Purity/Quality:

98%min ^*data from raw suppliers

5-Methylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-IMIDAZO[1,2-A]PYRIDINE

There total 4 articles about 5-METHYL-IMIDAZO[1,2-A]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Amino-6-methylpyridine (1824-81-3) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 5-methylimidazo[1,2-a]pyridine (933-69-7)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; for 22h; Heating;

DOI:10.1246/bcsj.72.1327

Reference yield: 70.0%

2-Amino-6-methylpyridine (1824-81-3) + 2-chloroethanal (107-20-0) → 5-methylimidazo[1,2-a]pyridine (933-69-7)

Guidance literature:

In ethanol; water; at 100 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.201705370

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) + bromoacetaldehyde (17157-48-1) → 5-methylimidazo[1,2-a]pyridine (933-69-7)

Guidance literature:

In ethanol; Heating;

DOI:10.1021/jm9507901

upstream raw materials:

2-Amino-6-methylpyridine

2-chloroethanal

bromoacetaldehyde

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

3-bromo-5-methylimidazo[1,2-a]pyridine

5-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

5-methylimidazo[1,2-a]pyridine-3-carbaldehyde

3-chloro-5-methylimidazo[1,2-a]pyridine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 0272. . Retrieved 2017/11/18.
• 2、 Tomoda, Haruhiko,Hirano, Takafumi,Saito, Shojiro,Mutai, Toshiki,Araki, Koji. "Substituent effects on fluorescent properties of imidazo[1,2- α]pyridine-based compounds". . p. 1327 - 1334. Retrieved 2007/10/03.