Technology Process of Zofenoprilat
There total 7 articles about Zofenoprilat which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / trimethylsilyl chloride / 10 h / Heating
2: 83 percent / 1-hydroxybenzotriazole; N,N-diisopropylethylamine; EDAC*HCl / tetrahydrofuran / 5 h
3: 3.0 g / N,N-diisopropylethylamine / 0.08 h / 60 °C
4: 20 mg / NaOH / methanol; H2O / 0.17 h / 50 °C
With
sodium hydroxide; chloro-trimethyl-silane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water;
3: Michael addition;
DOI:10.1016/j.bmc.2003.10.054
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 78 percent / p-TsOH / 18 h / Heating
2: 67 percent / tri-n-butylphosphine / benzene / 22 h
3: 1N NaOH
With
sodium hydroxide; tributylphosphine; toluene-4-sulfonic acid;
In
benzene;
DOI:10.1021/jm00401a014
