ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate

Base Information

• Chemical Name: ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate
• CAS No.: 137368-73-1
• Molecular Formula: C₃₂H₂₈N₃O₂P
• Molecular Weight: 517.567
• Mol file: 137368-73-1.mol

Synonyms:ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate

Chemical Property of ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate

There total 2 articles about ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl α-azido-β-<(1-phenyl)-5-pyrazolyl> acrylate (137368-72-0) + triphenylphosphine (603-35-0) → ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate (137368-73-1)

Guidance literature:

In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)82325-5

Reference yield:

1-phenyl-1H-pyrazole-5-carboxaldehyde (132274-70-5) → ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate (137368-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / Na / ethanol / 1) -15 deg C, 1 h, 2) rt, 7 h

2: 99 percent / CH₂Cl₂ / 4 h / Ambient temperature

With sodium; In ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)82325-5

Reference yield: 95.0%

carbon disulfide (75-15-0,12122-00-8) + ethyl β-<(1-phenyl)-5-pyrazolyl>-α-(triphenylphosphoranylidenamino)acrylate (137368-73-1) → 6-ethoxycarbonyl-1-phenyl-1H-pyrazolo<4,3-c>pyridine-4-thione (137368-89-9)

Guidance literature:

In toluene; at 165 ℃; for 28h;

DOI:10.1016/S0040-4020(01)82325-5

upstream raw materials:

ethyl α-azido-β-<(1-phenyl)-5-pyrazolyl> acrylate

triphenylphosphine

1-phenyl-1H-pyrazole-5-carboxaldehyde

Downstream raw materials:

(Z)-2-Isothiocyanato-3-(2-phenyl-2H-pyrazol-3-yl)-acrylic acid ethyl ester

6-ethoxycarbonyl-1-phenyl-1H-pyrazolo<4,3-c>pyridine-4-thione

(Z)-2-Isocyanato-3-(2-phenyl-2H-pyrazol-3-yl)-acrylic acid ethyl ester

(E)-2-[(Z)-1-Ethoxycarbonyl-2-(2-phenyl-2H-pyrazol-3-yl)-vinyliminomethyleneamino]-3-(2-phenyl-2H-pyrazol-3-yl)-acrylic acid ethyl ester

Refernces