Mercaptopurine

Base Information Edit

Chemical Name:Mercaptopurine
CAS No.:50-44-2
Deprecated CAS:5759-99-9,5818-33-7,5818-60-0,39454-94-9,111079-50-6,39454-94-9,5818-33-7,5818-60-0
Molecular Formula:C5H4N4S
Molecular Weight:152.18
Hs Code.:2933599090
European Community (EC) Number:200-037-4
NSC Number:759614,755
UNII:PKK6MUZ20G
DSSTox Substance ID:DTXSID0020810
Nikkaji Number:J2.298E
Wikipedia:Mercaptopurine
Wikidata:Q418529
NCI Thesaurus Code:C61832
RXCUI:1546028
Pharos Ligand ID:GVGMMZSCWXZJ
Metabolomics Workbench ID:43275
ChEMBL ID:CHEMBL1425
Mol file:50-44-2.mol

Synonyms:1,7-Dihydro-6H-purine-6-thione;6 Mercaptopurine;6 Mercaptopurine Monohydrate;6 Thiohypoxanthine;6 Thiopurine;6-Mercaptopurine;6-Mercaptopurine Monohydrate;6-Thiohypoxanthine;6-Thiopurine;6H-Purine-6-thione, 1,7-dihydro-;BW 57 323H;BW 57-323H;BW 57323H;Leupurin;Mecaptopurine Anhydrous;Mercaptopurina Wellcome;Mercaptopurine;Puri-Nethol;Purimethol;Purinethol

Suppliers and Price of Mercaptopurine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
6-Mercaptopurine
50mg
$ 283.00

Tocris
6-Mercaptopurine ≥99%(HPLC)
50
$ 52.00

CSNpharm
6-Mercaptopurine
100mg
$ 61.00

Crysdot
6-Mercaptopurine 98+%
25g
$ 145.00

ChemScene
6-Mercaptopurine 99.16%
10g
$ 69.00

ChemScene
6-Mercaptopurine 99.16%
25g
$ 134.00

Chemenu
1,7-Dihydro-6H-purine-6-thione 98%
25g
$ 122.00

Arctom
3,7-dihydro-6H-purine-6-thione ≥98%
25g
$ 135.00

Arctom
3,7-dihydro-6H-purine-6-thione ≥98%
10g
$ 67.00

Arctom
3,7-dihydro-6H-purine-6-thione ≥98%
50mg
$ 5.00

Total 146 raw suppliers

Chemical Property of Mercaptopurine Edit

Chemical Property:

Appearance/Colour:yellowish-greenish solid
Vapor Pressure:0mmHg at 25°C
Melting Point:241-244 °C
Refractive Index:1.828
Boiling Point:471.018 °C at 760 mmHg
PKA:7.77, 11.17(at 25℃)
Flash Point:238.663 °C
PSA：89.45000
Density:1.82 g/cm³
LogP:1.01550
Storage Temp.:Store at RT
Water Solubility.:124mg/L(25 oC)
XLogP3:0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:152.01566732
Heavy Atom Count:10
Complexity:190

Purity/Quality:

99% ^*data from raw suppliers

6-Mercaptopurine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Antineoplastic Agents
Canonical SMILES:C1=NC2=C(N1)C(=S)N=CN2
Recent ClinicalTrials:Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma
Recent EU Clinical Trials:A multicentre, randomized trial in adults with de novo Philadelphia-Chromosome positive acute lymphoblastic leukemia to assess the efficacy of ponatinib versus imatinib in combination with low-intensity chemotherapy, to compare end of therapy with indication for SCT versus TKI, blinatumomab and chemotherapy in optimal responders and to evaluate blinatumomab in suboptimal responders (GMALL-EVOLVE)
Recent NIPH Clinical Trials:Efficacy of mercaptopurine in leukemia patients with relapse after allogeneic stem cell transplantation
Uses antineoplastic, immonusupressant;inhibits purine nucleotide synthesis and metabolism Has a cytotoxicity effect
Therapeutic Function Cancer chemotherapy

Technology Process of Mercaptopurine

There total 27 articles about Mercaptopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 68-94-0
hypoxanthine

: 50-44-2
6-mercaptopurine

Guidance literature:: With pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane; In dimethylsulfone; at 165 - 175 ℃; for 0.25h;
DOI:10.1021/jo101865y