2-chloro-1,5-dimethoxy-3-propylbenzene

Base Information

• Chemical Name: 2-chloro-1,5-dimethoxy-3-propylbenzene
• CAS No.: 106533-81-7
• Molecular Formula: C₁₁H₁₅ClO₂
• Molecular Weight: 214.692
• Mol file: 106533-81-7.mol

Synonyms:2-chloro-1,5-dimethoxy-3-propylbenzene

Chemical Property of 2-chloro-1,5-dimethoxy-3-propylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-1,5-dimethoxy-3-propylbenzene

There total 3 articles about 2-chloro-1,5-dimethoxy-3-propylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dihydroxy-6-propylbenzoic acid ethyl ester (21855-51-6) → 2-chloro-1,5-dimethoxy-3-propylbenzene (106533-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / SO₂Cl₂ / diethyl ether / 2 h / Ambient temperature

2: 1.) 15percent aq. NaOH, 2.) conc. HCl / 1.) reflux, 3 h, 2.) reflux, 10 min

3: K₂CO₃ / acetone / 10 h

With hydrogenchloride; sodium hydroxide; sulfuryl dichloride; potassium carbonate; In diethyl ether; acetone;

Reference yield:

ethyl 5-chloro-2,4-dihydroxy-6-propylbenzoate (106533-80-6) → 2-chloro-1,5-dimethoxy-3-propylbenzene (106533-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 15percent aq. NaOH, 2.) conc. HCl / 1.) reflux, 3 h, 2.) reflux, 10 min

2: K₂CO₃ / acetone / 10 h

With hydrogenchloride; sodium hydroxide; potassium carbonate; In acetone;

Reference yield:

dimethyl sulfate (77-78-1) + 4-Chloro-5-propyl-benzene-1,3-diol → 2-chloro-1,5-dimethoxy-3-propylbenzene (106533-81-7)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Yield given;

upstream raw materials:

dimethyl sulfate

2,4-dihydroxy-6-propylbenzoic acid ethyl ester

ethyl 5-chloro-2,4-dihydroxy-6-propylbenzoate

Downstream raw materials:

didymic acid

2-chloro-4-iodo-1,5-dimethoxy-3-propylbenzene

Refernces