Cyclizine hydrochloride

Base Information

• Chemical Name: Cyclizine hydrochloride
• CAS No.: 303-25-3
• Molecular Formula: C18H23ClN2
• Molecular Weight: 302.847
• Hs Code.: 2933595960
• European Community (EC) Number: 206-136-9
• NSC Number: 169102
• UNII: W0O1NHP4WE
• Wikidata: Q27122290
• NCI Thesaurus Code: C76672
• Metabolomics Workbench ID: 57608
• ChEMBL ID: CHEMBL1324714
• Mol file: 303-25-3.mol

Synonyms:Cyclizine;Cyclizine HCl;Cyclizine Hydrochloride;HCl, Cyclizine;Hydrochloride, Cyclizine;Marezine

Chemical Property of Cyclizine hydrochloride

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 1.77E-05mmHg at 25°C
• Melting Point: 258-260 °C
• Refractive Index: 1.5749 (estimate)
• Boiling Point: 363.7 °C at 760 mmHg
• Flash Point: 159.1 °C
• PSA: 6.48000
• Density: 1.0551 (rough estimate)
• LogP: 3.70120
• Storage Temp.: Refrigerator
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 302.1549764
• Heavy Atom Count: 21
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

Cyclizine hydrochloride (European Pharmacopoeia (EP) Reference Standard) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 61-23/24/25-42/43
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
• Uses: Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic. Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli
• Therapeutic Function: Antinauseant

Technology Process of Cyclizine hydrochloride

There total 1 articles about Cyclizine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

N-benzhydryl-N'-methylpiperazine (82-92-8) → cyclizine hydrochloride (303-25-3)

Guidance literature:

With hydrogenchloride; In methanol; water; at 45 - 55 ℃; for 2h;

upstream raw materials:

N-benzhydryl-N'-methylpiperazine

Refernces