Trichotomine

Base Information

• Chemical Name: Trichotomine
• CAS No.: 53472-14-3
• Molecular Formula: C30H20N4O6
• Molecular Weight: 532.5
• Mol file: 53472-14-3.mol

Synonyms:Trichotomin;trichotomine;

Chemical Property of Trichotomine

Chemical Property:

• Boiling Point: 1115.7oC at 760 mmHg
• Flash Point: 628.6oC
• PSA: 146.80000
• Density: 1.75g/cm3
• LogP: 2.90660

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: A dimeric alkaloid, trichotomine occurs in the fruit of Clerodendron trichotomum. The novel structure has been elucidated from chemical and spectroscopic data.

Technology Process of Trichotomine

There total 9 articles about Trichotomine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H12N2O5(2-)*2K(1+) → Trichotomin (53472-14-3)

Guidance literature:

With acetic acid; In water; at 24 - 29 ℃; for 96h;

DOI:10.1246/bcsj.62.880

Reference yield:

α-ketoglutaric acid (328-50-7) → Trichotomin (53472-14-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.4 g / H₂O / 336 h / Ambient temperature

2: 0.49 g / methanol; diethyl ether / 4 h / Ambient temperature

3: 64 percent / HCl / methanol / 1 h / Heating

4: 77 percent / KOH / H₂O; methanol / 22 h / 26 - 30 °C

5: 13 mg / AcOH / H₂O / 96 h / 24 - 29 °C

With hydrogenchloride; potassium hydroxide; acetic acid; In methanol; diethyl ether; water;

DOI:10.1246/bcsj.62.880

Reference yield:

dimethyl 2-ketoglutarate (13192-04-6) → Trichotomin (53472-14-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / methanol / 24 h / Heating

2: 77 percent / KOH / H₂O; methanol / 22 h / 26 - 30 °C

3: 13 mg / AcOH / H₂O / 96 h / 24 - 29 °C

With potassium hydroxide; acetic acid; In methanol; water;

DOI:10.1246/bcsj.62.880

upstream raw materials:

α-ketoglutaric acid

dimethyl 2-ketoglutarate

(S)-tryptophan methyl ester hydrochloride

(1R,3S)-1-(2-Carboxy-ethyl)-2,3,4,9-tetrahydro-1H-β-carboline-1,3-dicarboxylic acid

Refernces

• 1、 Iwadare et al.. "". . p. 1177. Retrieved 1974.
• 2、 Irikawa, Hajime,Toyoda, Yasuhiro,Kumagai, Hiroaki,Okumura, Yasuaki. "Isolation of Four 2,3,5,6,11,11b-Hexahydro-3-oxo-1H-indolizinoindole-5-carboxylic Acids from Clerodendron Trichotomum Thunb and Properties of Their Derivatives". . p. 880 - 887. Retrieved 2007/10/02.