1-(1-Methyl-2-benzimidazolyl)ethanol

Base Information

• Chemical Name: 1-(1-Methyl-2-benzimidazolyl)ethanol
• CAS No.: 3319-28-6
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.22
• Hs Code.: 2933990090
• NSC Number: 44964
• Nikkaji Number: J49.840H
• ChEMBL ID: CHEMBL457956
• Mol file: 3319-28-6.mol

Synonyms:3319-28-6;1-(1-Methyl-2-benzimidazolyl)ethanol;1-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-ol;1-(1-methylbenzimidazol-2-yl)ethanol;2-(2-Hydroxyethyl)-3-methylbenzimidazole;Ethanol, 1-(1-methyl-2-benzimidazolyl)-;1H-Benzimidazole-2-methanol,alpha,1-dimethyl-(9CI);NSC 44964;BRN 0149924;1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanol;NSC44964;2-Benzimidazolemethanol, alpha,1-dimethyl-;5-23-11-00362 (Beilstein Handbook Reference);CHEMBL457956;F0783-0059;IFLab1_003793;SCHEMBL11697197;HMS1422M09;2-Benzimidazolemethanol,1-dimethyl-;NSC-44964;STK862388;AKOS000125644;AKOS016041812;IDI1_009900;1-(1-methyl-1H-benzimidazol-2-yl)ethanol;2-(alpha-hydroxyethyl)-1-methylbenzimidazole;CS-0159234;EN300-57294;1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethan-1-ol;Z57085731

Chemical Property of 1-(1-Methyl-2-benzimidazolyl)ethanol

Chemical Property:

• Vapor Pressure: 2.75E-05mmHg at 25°C
• Boiling Point: 343.1°Cat760mmHg
• Flash Point: 161.3°C
• PSA: 38.05000
• Density: 1.19g/cm³
• LogP: 1.62660
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 176.094963011
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

99% ^*data from raw suppliers

1-(1-Methyl-1H-benzo[d]imidazol-2-yl)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=NC2=CC=CC=C2N1C)O

Technology Process of 1-(1-Methyl-2-benzimidazolyl)ethanol

There total 12 articles about 1-(1-Methyl-2-benzimidazolyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-acetyl-1-methylbenzimidazole (942-25-6) → N-methyl-2-(α-hydroxyethyl)benzimidazole (3319-28-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; for 1h;

Reference yield: 90.6%

1-benzimidazol-2-ylethanol (16414-04-3,19018-24-7) + methyl iodide (74-88-4) → N-methyl-2-(α-hydroxyethyl)benzimidazole (3319-28-6)

Guidance literature:

With sodium hydroxide; In acetone;

DOI:10.1007/BF01164866

Reference yield: 80.0%

C12H14N2O2 (944061-74-9) → N-methyl-2-(α-hydroxyethyl)benzimidazole (3319-28-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910701265556

upstream raw materials:

LACTIC ACID

N-methylbenzene-1,2-diamine dihydrochloride

2-acetyl-1-methylbenzimidazole

dimethyl sulfate

Downstream raw materials:

2-acetyl-1-methylbenzimidazole

1-methyl-2-(α-chloroethyl)benzimidazole

1-methyl-2-(1-phenylethyl)-1H-benzo[d]imidazole

1-(1-methyl-1H-benzoimidazol-2-yl)-3-(4-nitro-phenyl)-propenone

Refernces

• 1、 Muller, Gilles,Riehl, James P.,Schenk, Kurt J.,Hopfgartner, Gerard,Piguet, Claude,Buenzli, Jean-Claude G.. "Lanthanide triple helical complexes with a chiral bis(benzimidazole)pyridine derivative". . p. 3101 - 3110. Retrieved 2002.
• 2、 Kankate, Rani S.,Gide, Parag S.,Belsare, Deepak P.. "Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives". . p. 1855 - 1863. Retrieved 2015/04/22.
• 3、 Dubey,Reddy, P.V.V. Prasada,Srinivas. "Alternate method for the synthesis of N-alkyl/aralkyl-2-(α-hydroxy alkyl/aralkyl)benzimidazoles via regiospecific acetylation". . p. 1675 - 1681. Retrieved 2008/02/01.