6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid

Base Information

• Chemical Name: 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid
• CAS No.: 55764-56-2
• Molecular Formula: C10H6N2O5
• Molecular Weight: 234.165
• Mol file: 55764-56-2.mol

Synonyms:

Chemical Property of 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 2E-10mmHg at 25°C
• Boiling Point: 490.2°C at 760 mmHg
• Flash Point: 250.3°C
• Density: 1.624g/cm³

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid

There total 15 articles about 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-quinolone-4-carboxylic acid (15733-89-8) → 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (55764-56-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at -5 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.05.096

Reference yield:

2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0) → 2-Oxy-6-nitro-chinolin-4-carbonsaeure (55764-56-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at -5 ℃;

DOI:10.1002/hlca.19500330412

Reference yield:

7-Nitro-2,3,4,5-tetrahydrobenzazepine-2,4,5-trione (125241-00-1) → 6-nitro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (55764-56-2)

Guidance literature:

With sodium hydroxide; at 55 ℃;

upstream raw materials:

2-hydroxyquinoline-4-carboxylic acid

malonic acid

5-nitroisatin

1-acetyl-5-nitroindoline-2,3-dione

Downstream raw materials:

6-Amino-2-hydroxy-cinchoninsaeure

2-chloro-6-nitro-quinoline-4-carboxylic acid

Refernces

• 1、 Dulla, Balakrishna,Wan, Baojie,Franzblau, Scott G.,Kapavarapu, Ravikumar,Reiser, Oliver,Iqbal, Javed,Pal, Manojit. "Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents". supporting information; experimental part. p. 4629 - 4635. Retrieved 2012/07/31.