Ethylenediamine-n,n'-diacetate

Base Information

• Chemical Name: Ethylenediamine-n,n'-diacetate
• CAS No.: 5657-17-0
• Molecular Formula: C6H12 N2 O4
• Molecular Weight: 176.172
• Mol file: 5657-17-0.mol

Synonyms:ethylenediamine-n,n'-diacetate

Chemical Property of Ethylenediamine-n,n'-diacetate

Chemical Property:

• Appearance/Colour: White powder.
• Vapor Pressure: 0Pa at 20℃
• Melting Point: 224-225 ºC
• Refractive Index: 1.4431 (estimate)
• Boiling Point: 307.77°C (rough estimate)
• PKA: pK1:6.42;pK2:9.46 (25°C)
• Flash Point: 203.7oC
• PSA: 98.66000
• Density: 1.3600 (rough estimate)
• LogP: -0.88340
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Soluble in warm water.
• XLogP3: -4.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 176.07970687
• Heavy Atom Count: 12
• Complexity: 131

Purity/Quality:

99.9% ^*data from raw suppliers

Ethylenediamine-N,N′-diacetic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C[NH2+]CC(=O)[O-])[NH2+]CC(=O)[O-]
• Uses: Ethylenediamine-N,N'-diacetic acid is acts as a chelating agent, used as a haemostatic. Ethylenediamine-N,N′-diacetic acid (EDDA) is a chelating agent that can be used to synthesize:Binary and ternary copper(II) complexes with potent proteasome inhibitory properties.Pd(EDDA) complexes which can coordinate with amino acids, peptides, or DNA units.

Technology Process of Ethylenediamine-n,n'-diacetate

There total 5 articles about Ethylenediamine-n,n'-diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

ethylenediamine (107-15-3,85404-18-8) + chloroacetic acid (79-11-8) → ethylenediaminediacetic acid (5657-17-0)

Guidance literature:

ethylenediamine; chloroacetic acid; In ethanol; at 20 ℃; for 1h;

With potassium hydroxide; In ethanol; for 1h; Reflux;

Reference yield:

ethylenediaminetetraacetic acid (60-00-4,94108-75-5) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylenediaminediacetic acid (5657-17-0) + carbon dioxide (124-38-9,18923-20-1)

Guidance literature:

With trans-cyclohexane-1,2-diamine-N,N,N',N'-tetraacetatomanganate(III); sodium perchlorate; In water; at 30 ℃; Rate constant; Mechanism; variation of oxidant concentration; acetate or borate buffer;

DOI:10.1039/DT9910002729

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + hydrogen cyanide (74-90-8) + ethylenediamine (107-15-3,85404-18-8) → ethylenediaminediacetic acid (5657-17-0)

Guidance literature:

With water; calcium cyanide; at 45 ℃; und Kochen des gebildeten Dinitrils mit wss.NaOH;

upstream raw materials:

formaldehyd

hydrogen cyanide

ethylenediamine

sodium cyanide

Downstream raw materials:

N,N'-ethylenebis[N-(o-hydroxybenzyl)glycine]

2-(2-oxopiperazino)acetic acid

N,N'-DI(2-HYDROXY, 5-ACETAMIDOBENZYL)ETHYLENEDIAMINE-N,N'-DIACETIC ACID

4-(o-hydroxybenzyl)-2 piperazone-1-acetic acid

Refernces

• 1、 Sun, Yanyan,Chen, Lei,Wu, Xiwen,Ding, Qian. "Bifunctional bisphosphonate derivatives and platinum complexes with high affinity for bone hydroxyapatite". . p. 1070 - 1075. Retrieved 2017/09/30.
• 2、 -. "Amides, method for preparing the amides, and detergent compositions containing the amides". . . Retrieved 2008/06/13.