ISOPROTERENOL HYDROCHLORIDE

Base Information

• Chemical Name: ISOPROTERENOL HYDROCHLORIDE
• CAS No.: 949-36-0
• Molecular Formula: C₁₁H₁₈NO₃*Cl
• Molecular Weight: 247.722
• Mol file: 949-36-0.mol

Synonyms:Benzylalcohol, 3,4-dihydroxy-a-[(isopropylamino)methyl]-, hydrochloride (8CI);Protocatechuyl alcohol, a-(isopropylaminomethyl)-,hydrochloride (5CI);3,4-Dihydroxy-a-(isopropylaminomethyl)benzylalcohol hydrochloride;Aerolone;Aerotrol;Asthpul;DL-Isoprenalinehydrochloride;DL-Isoproterenol hydrochloride;Euspiran;Isadrine;Isomenyl;Isoprel;Isoprenaline chloride;Isoprenaline hydrochloride;Isopropylarterenolhydrochloride;Isoproterenol hydrochloride;Isovon;Isuprel;Mistarel;NSC37745;NSC 89747;Proternol;Saventrine;Suscardia;Vapo-Iso;dl-Isadrinehydrochloride;dl-Isoprenaline hydrochloride;dl-Isopropylnoradrenalinehydrochloride;dl-Isopropylnorepinephrine hydrochloride;dl-Isoproterenolhydrochloride;a-(Isopropylaminomethyl)-3,4-dihydroxybenzylalcohol hydrochloride;

Chemical Property of ISOPROTERENOL HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.02E-07mmHg at 25°C
• Melting Point: 165-175 °C (dec.)(lit.)
• Boiling Point: 417.5°Cat760mmHg
• Flash Point: 179.7°C
• PSA: 72.72000
• Density: 1.199g/cm³
• LogP: 2.32210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of ISOPROTERENOL HYDROCHLORIDE

There total 6 articles about ISOPROTERENOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

Isoproterenone hydrochloride (16899-81-3) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; pyrographite; In water; at 35 ℃; under 3750.38 Torr; Pressure; Temperature; Autoclave;

Reference yield: 85.7%

Isoproterenone (121-28-8) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 25 ℃; for 4h; Time;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → isoproterenol hydrochloride (51-30-9,949-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc(II) chloride / 1,2-dichloro-ethane / 0.5 h / 10 - 15 °C

1.2: 20 h / 70 °C

2.1: triethylamine / ethanol / 10 h / 10 - 40 °C

3.1: pyrographite; 5%-palladium/activated carbon; hydrogen / water / 35 °C / 3750.38 Torr / Autoclave

With 5%-palladium/activated carbon; hydrogen; pyrographite; triethylamine; zinc(II) chloride; In ethanol; water; 1,2-dichloro-ethane;

upstream raw materials:

(-)-isoproterenol hydrochloride

Isoproterenone

Isoproterenone hydrochloride

benzene-1,2-diol

Downstream raw materials:

tris(carboethoxy)isoproterenol

isoproterenol hydrochloride

(+)-Isoproterenol hydrochloride

(R)-(-)-isoproterenol hydrochloride

Refernces

• 1、 -. "Hydrochloric acid isopropyl adrenergic preparation method". Paragraph 0014; 0019-0021; 0026-0028; 0033-0034. . Retrieved 2019/03/31.
• 2、 Bosak, Anita,Smilovi?, Ivana Gazi?,?inko, Goran,Vinkovi?, Vladimir,Kovarik, Zrinka. "Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors". body text. p. 6716 - 6723. Retrieved 2012/09/22.