Aminopromazine

Base Information

• Chemical Name: Aminopromazine
• CAS No.: 58-37-7
• Molecular Formula: C19H25N3S
• Molecular Weight: 327.494
• European Community (EC) Number: 200-378-9
• UNII: S9SDD93U5U
• DSSTox Substance ID: DTXSID00861592
• Nikkaji Number: J10.682H
• Wikidata: Q27289096
• NCI Thesaurus Code: C76457
• RXCUI: 2462496
• Metabolomics Workbench ID: 155563
• ChEMBL ID: CHEMBL2105961
• Mol file: 58-37-7.mol

Synonyms:AMINOPROMAZINE;Proquamezine;58-37-7;Tetrameprozine;aminopropazine;Aminopromazin;Aminopromazina;Aminopromazinum;Iminopromazine;10-[2,3-Bis(Dimethylamino)propyl]phenothiazine;10-(2,3-Bis(dimethylamino)propyl)phenothiazine;UNII-S9SDD93U5U;S9SDD93U5U;Aminopromazinum [INN-Latin];N,N,N',N'-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine;Aminopromazina [INN-Spanish];Aminopromazine [INN:BAN:DCF];1-N,1-N,2-N,2-N-tetramethyl-3-phenothiazin-10-ylpropane-1,2-diamine;EINECS 200-378-9;Jenotone;Lispamol;1,2-Propanediamine, N,N,N',N'-tetramethyl-3-(10H-phenothiazin-10-yl)-;C19H25N3S;RP 3828;aminopromazin-;PROQUAMAZINE;Bayer A 124;Aminopromazine [DCF:INN];Aminopromazine [INN:DCF];AMINOPROMAZINE [MI];AMINOPROMAZINE [INN];SCHEMBL25156;CHEMBL2105961;DTXSID00861592;CHEBI:135400;MFCD00865180;AKOS030228533;DB15596;3828 R. P.;Phenothiazine, 10-[2,3-bis(dimethylamino)propyl]-;[Bis(dimethylamino)-2',3'-propyl]-10-phenothiazine;Q27289096;N1,N1,N2,N2-Tetramethyl-3-(10H-phenothiazin-10-yl)-1,2-propanediamine

Chemical Property of Aminopromazine

Chemical Property:

• Vapor Pressure: 4.55E-08mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 443.671 °C at 760 mmHg
• Flash Point: 222.124 °C
• PSA: 35.02000
• Density: 1.123 g/cm³
• LogP: 3.84610
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 327.17691898
• Heavy Atom Count: 23
• Complexity: 352

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
• Therapeutic Function: Spasmolytic

Technology Process of Aminopromazine

There total 2 articles about Aminopromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10H-phenothiazine (92-84-2) + 1,3-bis(dimethylamino)-2-chloropropane (40550-12-7) → Proquamezin (58-37-7) + tetra-N-methyl-2-phenothiazin-10-yl-propanediyldiamine (102322-18-9)

Guidance literature:

With sodium amide; xylene;

Reference yield:

→ Proquamezin (58-37-7)

Guidance literature:

Ester I (Erhitzen);

upstream raw materials:

10H-phenothiazine

1,3-bis(dimethylamino)-2-chloropropane

Refernces