Ethyl Biscoumacetate

Base Information

• Chemical Name: Ethyl Biscoumacetate
• CAS No.: 548-00-5
• Molecular Formula: C22H16O8
• Molecular Weight: 408.364
• Hs Code.: 2932209090
• Mol file: 548-00-5.mol

Synonyms:Pelentan;Bisoxycumarin-essigsaeureethylester;Neodicoumarol;Trombolysan;Ethylbiscoumacetat;Trombil;Neodicumarinum;Neodicumarol;Ethylbiscum-acetat;ETHYL BISCOUMACETATE;Neodicoumarin;Trombarin;Tromexan;

Chemical Property of Ethyl Biscoumacetate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 177-182° and mp 154-157°
• Refractive Index: 1.4480 (estimate)
• Boiling Point: 666.624°C at 760 mmHg
• PKA: pKa 7.5 (Uncertain)
• Flash Point: 238.093°C
• PSA: 127.18000
• Density: 1.542g/cm³
• LogP: 3.00560
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• Water Solubility.: 54.31mg/L(temperature not stated)

Purity/Quality:

95-99% ^*data from raw suppliers

EthylBiscoumacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Medicine (anticoagulant).
• Therapeutic Function: Anticoagulant

Technology Process of Ethyl Biscoumacetate

There total 1 articles about Ethyl Biscoumacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

glyoxylic acid ethyl ester (924-44-7) + 4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) → ethyl biscoumacetate (548-00-5)

Guidance literature:

In ethanol; toluene; for 16h; Reflux;

DOI:10.1021/jm9011609

Reference yield:

ethyl biscoumacetate (548-00-5) → 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-4-(2-hydroxy-phenyl)-4-oxo-butyric acid

Guidance literature:

With sodium hydroxide;

upstream raw materials:

glyoxylic acid ethyl ester

4-hydroxy[1]benzopyran-2-one

Refernces