1,1,3,3-Tetraethoxypropane

Base Information

• Chemical Name: 1,1,3,3-Tetraethoxypropane
• CAS No.: 122-31-6
• Molecular Formula: C11H24O4
• Molecular Weight: 220.309
• Hs Code.: 29110000
• European Community (EC) Number: 204-533-1
• NSC Number: 17068
• UNII: G7ZMW723R7
• DSSTox Substance ID: DTXSID70153456
• Nikkaji Number: J36.835K
• Wikidata: Q27278908
• Mol file: 122-31-6.mol

Synonyms:1,1,3,3-tetraethoxypropane

Chemical Property of 1,1,3,3-Tetraethoxypropane

Chemical Property:

• Appearance/Colour: clear colourless to yellow liquid
• Vapor Pressure: 0.302mmHg at 25°C
• Melting Point: -90 °C
• Refractive Index: n20/D 1.411(lit.)
• Boiling Point: 220 °C at 760 mmHg
• Flash Point: 42.2 °C
• PSA: 36.92000
• Density: 0.932 g/cm³
• LogP: 2.17470
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Water Solubility.: insoluble
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 220.16745924
• Heavy Atom Count: 15
• Complexity: 104

Purity/Quality:

99% ^*data from raw suppliers

1,1,3,3-Tetraethoxypropane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36/37/39-26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Acetals
• Canonical SMILES: CCOC(CC(OCC)OCC)OCC
• Uses: Organic synthesis. 1,1,3,3-Tetraethoxypropane has been used in the preparation of diazabicyclodecenes.

Technology Process of 1,1,3,3-Tetraethoxypropane

There total 31 articles about 1,1,3,3-Tetraethoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

trimethylsiloxyethene (6213-94-1) + orthoformic acid triethyl ester (122-51-0) → malondialdehyde bis(diethyl acetal) (122-31-6)

Guidance literature:

With zinc(II) chloride; In ethyl acetate; for 3h; Ambient temperature;

Reference yield: 70.0%

ethanol (64-17-5) + cyclohexa-1,4-diene (1165952-92-0) → malondialdehyde bis(diethyl acetal) (122-31-6) + ethyl 3,3-diethoxypropanoate (10601-80-6) + diethyl malonate (105-53-3)

Guidance literature:

With hydrogenchloride; ozone; -40 deg C, then ca. 30 min reflux;

Reference yield: 69.2%

ethyl vinyl ether (109-92-2,25104-37-4) + orthoformic acid triethyl ester (122-51-0) → malondialdehyde bis(diethyl acetal) (122-31-6)

Guidance literature:

ethyl vinyl ether; orthoformic acid triethyl ester; With boron trifluoride diethyl etherate; at 20 - 38 ℃;

With potassium carbonate; at 20 ℃; for 2h;

upstream raw materials:

1,3,3-triethoxypropene

ethanol

acetic acid-(1,3,3-triethoxy-propyl ester)

ethyl vinyl ether

Downstream raw materials:

PYRIMIDINE

1,3-bis-(2,3-diphenyl-6,7-dihydro-5H-thiazolo[3,2-a]pyridin-8-yl)-trimethinium; perchlorate

Benzothieno<3,2-b>pyridine

pyrimido<1,2-a>pyrimidinium perchlorate

Refernces

• 1、 Cai, Zhenping,Chen, Rujia,Jiang, Lilong,Li, Fukun,Li, Xuehui,Long, Jinxing,Zhang, Hao. "One-pot production of diethyl maleate via catalytic conversion of raw lignocellulosic biomass". supporting information. p. 10116 - 10122. Retrieved 2021/12/24.
• 2、 -. "PROCESS FOR PRODUCING TETRAALKOXYPROPANE AND DERIVATIVE THEREOF". Page/Page column 6. . Retrieved 2008/06/13.