Technology Process of (4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one
There total 4 articles about (4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane;
at 40 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/jo200466t
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: C38H55CoN2O4; water
2.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -30 °C
2.2: 2 h / -30 °C
3.1: triethylamine / dichloromethane / 1 h / -78 °C
4.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 72 h / 40 °C / Inert atmosphere
With
copper(l) iodide; Hoveyda-Grubbs catalyst second generation; C38H55CoN2O4; water; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo200466t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -30 °C
1.2: 2 h / -30 °C
2.1: triethylamine / dichloromethane / 1 h / -78 °C
3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 72 h / 40 °C / Inert atmosphere
With
copper(l) iodide; Hoveyda-Grubbs catalyst second generation; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo200466t