Acetohydroxamic acid, 2-(2-thenylcarboxamido)-

Base Information

• Chemical Name: Acetohydroxamic acid, 2-(2-thenylcarboxamido)-
• CAS No.: 65654-13-9
• Molecular Formula: C7H8N2O3S
• Molecular Weight: 200.23
• DSSTox Substance ID: DTXSID00215894
• Nikkaji Number: J86.342D
• Wikidata: Q83092016
• Mol file: 65654-13-9.mol

Synonyms:BRN 5530790;N-(2-Thenoyl)glycinohydroxamic acid;ACETOHYDROXAMIC ACID, 2-(2-THENYLCARBOXAMIDO)-;2-Thiophenecarboxamide, N-(2-(hydroxyamino)-2-oxoethyl)-;65654-13-9;DTXSID00215894;2-(2-Thienylcarbonylamino)acetohydroxamic acid;N-HYDROXY-2-(THIOPHEN-2-YLFORMAMIDO)ACETAMIDE

Chemical Property of Acetohydroxamic acid, 2-(2-thenylcarboxamido)-

Chemical Property:

• Density: 1.438g/cm³
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 200.02556330
• Heavy Atom Count: 13
• Complexity: 210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(=O)NCC(=O)NO

Technology Process of Acetohydroxamic acid, 2-(2-thenylcarboxamido)-

There total 4 articles about Acetohydroxamic acid, 2-(2-thenylcarboxamido)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H13N2O4PolS → Thiophene-2-carboxylic acid hydroxycarbamoylmethyl-amide (65654-13-9)

Guidance literature:

With hydroxylamine; sodium hydroxide; In water; isopropyl alcohol; for 15h; Inert atmosphere; solid phase reaction;

DOI:10.1016/j.tetlet.2011.10.103

Reference yield:

N-(thiophene-2-carbonyl)-glycine ethyl ester (39978-25-1) → Thiophene-2-carboxylic acid hydroxycarbamoylmethyl-amide (65654-13-9)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; Yield given;

DOI:10.1248/cpb.28.2045

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) → Thiophene-2-carboxylic acid hydroxycarbamoylmethyl-amide (65654-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / CHCl₃; H₂O / 0 - 10 °C

2: NH₂OH*HCl, KOH / methanol

With potassium hydroxide; hydroxylamine hydrochloride; potassium carbonate; In methanol; chloroform; water;

DOI:10.1248/cpb.28.2045

upstream raw materials:

N-(thiophene-2-carbonyl)-glycine ethyl ester

2-Thiophenecarbonyl chloride

2-thiophenylcarboxylic acid

Refernces

• 1、 Munakata,Tanaka,Toyoshima. "Therapy for urolithiasis with hydroxamic acids. I. Synthesis of new N-(aroyl)glycinohydroxamic acid derivatives and related compounds". . p. 2045 - 2051. Retrieved 2007/10/02.