Friedelanol

Base Information

• Chemical Name: Friedelanol
• CAS No.: 5085-72-3
• Molecular Formula: C₃₀H₅₂O
• Molecular Weight: 428.742
• Nikkaji Number: J12.755H
• Wikidata: Q104667641
• Metabolomics Workbench ID: 127878
• ChEMBL ID: CHEMBL229563
• Mol file: 5085-72-3.mol

Synonyms:3beta-friedelinol;epi-friedelinol;epifriedelanol;friedelanol;friedelinol;friedelinol, (3beta)-isomer

Chemical Property of Friedelanol

Chemical Property:

• Vapor Pressure: 3.71E-11mmHg at 25°C
• Melting Point: 301-304 °C
• Boiling Point: 478.3°C at 760 mmHg
• PKA: 15.18±0.70(Predicted)
• Flash Point: 199.6°C
• Density: 0.966g/cm³
• XLogP3: 10.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 428.401816278
• Heavy Atom Count: 31
• Complexity: 741

Purity/Quality:

99% ^*data from raw suppliers

Friedelanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C(CCC2C1(CCC3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C)C)C)C)C)C)O
• Isomeric SMILES: C[C@H]1[C@@H](CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C)C)O

Technology Process of Friedelanol

There total 34 articles about Friedelanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

friedelin (559-74-0) → epifriedelanol (5085-72-3,7506-18-5,16844-71-6,105370-95-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at -78 - 20 ℃;

DOI:10.1021/np010217m

Reference yield: 100.0%

friedelin (559-74-0) → friedelinol (7506-18-5,16844-71-6,105370-95-4,5085-72-3)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium; In butan-1-ol; for 1.5h; Heating;

DOI:10.1021/np010217m

Reference yield: 75.0%

3β,24-oxido-D:A-friedooleanane (2735-84-4) → epifriedelanol (5085-72-3,7506-18-5,16844-71-6,105370-95-4) + D:A friedoolean-24-ol (2130-12-3)

Guidance literature:

With lithium; In ethylenediamine;

DOI:10.1016/S0040-4039(00)88490-7

upstream raw materials:

friedelin

D:A-friedo-oleanane

3α-acetoxyfriedelan

3-oxo-D:A-friedo-oleanan-25-yl-acetate

Downstream raw materials:

friedel-3⁽⁴⁾-ene

friedelin

3β-acetoxy-friedelane

friedel-2-ene

Refernces

• 1、 Dinda,De,Bhattacharya,Arima,Sato,Harigaya. "Chemical constituents of Argyreia argentea, Millingtonia hortensis and Pyrostegia venusta". . p. 291 - 293. Retrieved 2007/10/03.
• 2、 Moiteiro,Justino,Tavares,Marcelo-Curto,Florencio,Nascimento,Pedro,Cerqueira,Pinto. "Synthetic secofriedelane and friedelane derivatives as inhibitors of human lymphocyte proliferation and growth of human cancer cell lines in vitro". . p. 1273 - 1277. Retrieved 2007/10/03.