2,4-DIHYDROXYBENZHYDRAZIDE

Base Information

• Chemical Name: 2,4-DIHYDROXYBENZHYDRAZIDE
• CAS No.: 13221-86-8
• Molecular Formula: C7H8 N2 O3
• Molecular Weight: 168.152
• Hs Code.: 2928000090
• Mol file: 13221-86-8.mol

Synonyms:b-Resorcylic acid, hydrazide(6CI,7CI,8CI); 2,4-Dihydroxybenzohydrazide; 2,4-Dihydroxybenzoic acidhydrazide; 4-Hydroxysalicylic acid hydrazide

Chemical Property of 2,4-DIHYDROXYBENZHYDRAZIDE

Chemical Property:

• Melting Point: 247-250 °C(lit.)
• Boiling Point: °Cat760mmHg
• PKA: 8.22±0.35(Predicted)
• Flash Point: °C
• PSA: 95.58000
• Density: 1.477g/cm³
• LogP: 0.79250
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dihydroxybenzoic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dihydroxybenzoic acid hydrazide may be used in the synthesis of:2,4-dihydroxy-N′-(4-methoxybenzylidene)benzohydrazide2,4-dihydroxy-N′-(2-hydroxy-4-methoxybenzylidene)benzohydrazide(E)-2,4-dihydroxy-N′-(2-hydroxy-3-methoxy-5-nitrobenzylidene) benzohydrazide dihydrate[N′-(5-chloro-2-oxidobenzyl-κO)-2,4-dihydroxybenzohydrazidato-κ2N′,O](methanol-κO)dioxidomolybdenum(VI)–4,4′-bipyridine(E)-N′-(3,4-dimethoxybenzylidene)-2,4-dihydroxybenzohydrazide methanol solvate

Technology Process of 2,4-DIHYDROXYBENZHYDRAZIDE

There total 6 articles about 2,4-DIHYDROXYBENZHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2,4-dihydroxybenzoate (2150-47-2) → 2,4-dihydroxybenzoic acid hydrazide (13221-86-8)

Guidance literature:

With hydrazine; In methanol; for 48h; Heating;

DOI:10.1016/j.tet.2007.09.031

Reference yield: 85.2%

→ 2,4-dihydroxybenzoic acid hydrazide (13221-86-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

Reference yield: 73.0%

ethyl 2,4-dihydroxybenzoate (4143-00-4) → 2,4-dihydroxybenzoic acid hydrazide (13221-86-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 9h; Reflux;

DOI:10.1016/j.molliq.2021.116911

upstream raw materials:

ethyl 2,4-dihydroxybenzoate

methyl 2,4-dihydroxybenzoate

4-hydroxysalicylic acid

2,4-dihydroxybenzoyl chloride

Downstream raw materials:

1-(2,4-dihydroxy-benzoyl)-4-(4-methoxy-phenyl)-thiosemicarbazide

1-(2,4-dihydroxy-benzoyl)-4-(2-fluorophenyl)-thiosemicarbazide

2,4-dihydroxy-N'-(4-methoxybenzylidene)benzohydrazide

(2,4-dihydroxyphenyl)(3,5-dimethyl-1H-pyrazol-1-yl)methanone

Refernces

• 1、 Gamov,Kiselev,Murekhina,Zavalishin,Aleksandriiskii,Kosterin, D.Yu.. "Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs". . . Retrieved 2021/07/16.
• 2、 Bogdanovi?, Goran A.,Brankovi?, Jovica,Milovanovi?, Vesna,Mladenovi?, Milan,Novakovi?, Sla?ana,Petrovi?, Vladimir P.,Petrovi?, Zorica D.,Simijonovi?, Du?ica. "Pyrazole derivatives of medically relevant phenolic acids: Insight into antioxidative and anti-lox activity". . p. 807 - 819. Retrieved 2021/10/21.