Deoxyuridine-5'-diphosphate

Base Information

• Chemical Name: Deoxyuridine-5'-diphosphate
• CAS No.: 4208-67-7
• Molecular Formula: C9H14N2O11P2
• Molecular Weight: 388.16
• DSSTox Substance ID: DTXSID90194922
• Nikkaji Number: J699.272B
• Wikidata: Q60573941
• Metabolomics Workbench ID: 37540
• ChEMBL ID: CHEMBL9519
• Mol file: 4208-67-7.mol

Synonyms:dUDP;DEOXYURIDINE-5'-DIPHOSPHATE;2'-Deoxyuridine 5'-diphosphate;4208-67-7;deoxyuridine-diphosphate;Deoxyuridine diphosphate;Uridine 5'-(trihydrogen diphosphate), 2'-deoxy-;2'-deoxyuridine-5'-diphosphate;CHEMBL9519;CHEBI:28850;Uridine, 2'-deoxy-, 5'-(trihydrogen pyrophosphate);DUD;1dud;D0RV7M;Deoxyuridine 5'-diphosphate;SCHEMBL156694;DTXSID90194922;C9H14N2O11P2;2''-Deoxyuridine-5''-diphosphate;BDBM50179185;DEOXYURIDINE-5''-DIPHOSPHATE;C9-H14-N2-O11-P2;DB03413;Uridine, 2'-deoxy-, 5'-pyrophosphatel;2'-deoxyuridine 5'-(trihydrogen diphosphate);C01346;Q60573941;((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate;[({[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid;2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-D-erythro-pentofuranosyl]-

Chemical Property of Deoxyuridine-5'-diphosphate

Chemical Property:

• PSA: 217.49000
• LogP: -1.17640
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 6
• Exact Mass: 388.00728326
• Heavy Atom Count: 24
• Complexity: 645

Purity/Quality:

99%, ^*data from raw suppliers

2'-Deoxyuridine-5'-diphosphate triethylammonium salt - 10 mM aqueous solution ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)O)O
• Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)O)O

Technology Process of Deoxyuridine-5'-diphosphate

There total 3 articles about Deoxyuridine-5'-diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

uridine (58-96-8) → dUDP (4208-67-7)

Guidance literature:

Multistep reaction;

DOI:10.1021/ol0521432

Reference yield:

2'-deoxyuridine-5'-triphosphate (1173-82-6,94234-60-3) → dUDP (4208-67-7)

Guidance literature:

With HCl buffer; N-methylhydantoin amidohydrolase; potassium chloride; uracil; 2-amino-2-hydroxymethyl-1,3-propanediol; magnesium chloride; at 37 ℃; for 0.5h; Product distribution; Rate constant; various nucleoside triphosphates under different conditions, hydrolysis;

Reference yield:

2'-deoxyuridine-5'-monophosphate (964-26-1) → dUDP (4208-67-7)

Guidance literature:

With Mycobacterium tuberculosis; ATP; Enzyme kinetics;

DOI:10.1016/S0960-894X(03)00643-7

upstream raw materials:

2'-deoxyuridine-5'-triphosphate

2'-deoxyuridine-5'-monophosphate

uridine

Refernces

• 1、 Ahmadibeni, Yousef,Parang, Keykavous. "Selective diphosphorylation, dithiodiphosphorylation, triphosphorylation, and trithiotriphosphorylation of unprotected carbohydrates and nucleosides". . p. 5589 - 5592. Retrieved 2007/10/03.