4-Hydroxystyrene

Base Information

• Chemical Name: 4-Hydroxystyrene
• CAS No.: 2628-17-3
• Molecular Formula: C8H8O
• Molecular Weight: 120.151
• Hs Code.: 29089990
• European Community (EC) Number: 220-103-6
• NSC Number: 114470
• UNII: OA7V1SM8YL
• DSSTox Substance ID: DTXSID7073301
• Nikkaji Number: J38.247G
• Wikipedia: 4-Vinylphenol
• Wikidata: Q4637201
• Metabolomics Workbench ID: 38454
• ChEMBL ID: CHEMBL349881
• Mol file: 2628-17-3.mol

Synonyms:Phenol,p-vinyl- (6CI,7CI,8CI);4-Ethenylphenol;4-Hydroxystyrene;4-Vinylphenol;p-Hydroxystyrene;p-Vinylphenol;

Chemical Property of 4-Hydroxystyrene

Chemical Property:

• Vapor Pressure: 9.38hPa at 25℃
• Melting Point: 73 °C
• Refractive Index: 1.4440
• Boiling Point: 206.2 °C at 760 mmHg
• PKA: 9.95±0.26(Predicted)
• Flash Point: 92.3 °C
• PSA: 20.23000
• Density: 1.055 g/cm³
• LogP: 2.03520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Chloroform (Sparingly), DMSO (Slightly)
• Water Solubility.: Slightly miscible with water.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 120.057514874
• Heavy Atom Count: 9
• Complexity: 90.7

Purity/Quality:

99%, ^*data from raw suppliers

4-Vinylphenol,10wt.%InPropyleneGlycol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC1=CC=C(C=C1)O
• Uses: 4-Vinylphenol, 10 wt.% In Propylene Glycol can be used as a perfume oil mixture.

Technology Process of 4-Hydroxystyrene

There total 78 articles about 4-Hydroxystyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

para-coumaric acid (7400-08-0,50940-26-6) → 4-Vinylphenol (2628-17-3,24979-70-2)

Guidance literature:

With sodium hydroxide; at 160 ℃; for 5h;

Reference yield: 98.0%

malonic acid (141-82-2) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-Vinylphenol (2628-17-3,24979-70-2)

Guidance literature:

With ethylenediamine; In N,N-dimethyl-formamide; at 150 ℃; for 6h; Reagent/catalyst; Solvent; Large scale;

Reference yield: 97.0%

p-Coumaric Acid (7400-08-0,50940-26-6) → 4-Vinylphenol (2628-17-3,24979-70-2)

Guidance literature:

With 4-methoxy-phenol; In water; N,N-dimethyl-formamide; at 150 ℃; for 4h; Solvent;

upstream raw materials:

4-Ethylphenol

p-acetoxystyrene

p-Coumaric Acid

4-vinylphenyl benzoate

Downstream raw materials:

3-(4-vinylphenyloxy)-1-propene

4-Methoxystyrene

1-(2-{2-[2-Hydroxy-3-(4-vinyl-phenoxy)-propoxy]-ethoxy}-ethoxy)-3-(4-vinyl-phenoxy)-propan-2-ol

12-bromododecyl 4-styryl ether

Refernces

• 1、 -. "MODIFIED MONOMER, MODIFIED POLYMER COMPRISING THE SAME AND METHOD FOR PREPARING THEM". Paragraph 0188-0191. . Retrieved 2021/05/18.
• 2、 Zhao, Mingtao,Hong, Xulin,Abdullah,Yao, Ruilian,Xiao, Yi. "Rapid biosynthesis of phenolic glycosides and their derivatives from biomass-derived hydroxycinnamates". . p. 838 - 847. Retrieved 2021/02/09.