1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione

Base Information

• Chemical Name: 1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione
• CAS No.: 4668-74-0
• Molecular Formula: C20H28O6
• Molecular Weight: 364.43
• Mol file: 4668-74-0.mol

Synonyms:Phenanthro(10,1-bc)pyran-5,10-dione,1,2,3,3abeta,4,6abeta,7,7aalpha,11,11a,11balpha,11c-dodecahydro-1beta,2alpha,11beta-trihydroxy-3alpha,8,11abeta,11cbeta-tetramethyl;Klaineanone;

Chemical Property of 1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 570.952°C at 760 mmHg
• Flash Point: 202.091°C
• PSA: 104.06000
• Density: 1.3g/cm³
• LogP: 0.82820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione

There total 12 articles about 1β,11β,12α-Trihydroxypicras-3-ene-2,16-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(1β,11α,12α)-11,12-Epoxy-1-hydroxypicras-3-ene-2,16-dione (115481-44-2) → (+/-)-Klaineanone (4668-74-0,83914-24-3)

Guidance literature:

With perchloric acid; In tetrahydrofuran; dichloromethane; for 36h; Ambient temperature;

DOI:10.1021/ja00198a046

Reference yield:

(3S,3aS,6aR,7aS,10S,11aS,11bS,11cS)-10-Hydroxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,10,11a,11b,11c-octahydro-3H,4H-6-oxa-benzo[de]anthracene-5,11-dione (115464-26-1) → (+/-)-Klaineanone (4668-74-0,83914-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / potassium carbonate / methanol

2: 80 percent / MCPBA / CH₂Cl₂ / 1.) O deg C, 35 min; 2.) r.t, 2.5 h

3: 76 percent / 23percent perchloric acid / tetrahydrofuran; CH₂Cl₂ / 36 h / Ambient temperature

With perchloric acid; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ja00224a050

Reference yield:

(1β)-1-Hydroxypicras-3,11-diene-2,16-dione (115464-27-2) → (+/-)-Klaineanone (4668-74-0,83914-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / MCPBA / CH₂Cl₂ / 1.) O deg C, 35 min; 2.) r.t, 2.5 h

2: 76 percent / 23percent perchloric acid / tetrahydrofuran; CH₂Cl₂ / 36 h / Ambient temperature

With perchloric acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00224a050

upstream raw materials:

(1β,11α,12α)-11,12-Epoxy-1-hydroxypicras-3-ene-2,16-dione

(1β,16β)-1,16-Dimethoxypicras-11-ene

(1β)-1-Hydroxypicras-11-en-16-one

(1β)-1-Methoxypicras-11-en-16-one

Refernces

• 1、 Grieco, Paul A.,Nargund, Ravi P.,Parker, David T.. "Total Synthesis of the Highly Oxygenated Quassinoid (+/-)-Klaineanone". . p. 6287 - 6294. Retrieved 2007/10/02.