1-chloro-3-hydroxy-5,5-dimethylcyclohexene

Base Information

• Chemical Name: 1-chloro-3-hydroxy-5,5-dimethylcyclohexene
• CAS No.: 76181-36-7
• Molecular Formula: C₈H₁₃ClO
• Molecular Weight: 160.644
• Mol file: 76181-36-7.mol

Synonyms:1-chloro-3-hydroxy-5,5-dimethylcyclohexene

Chemical Property of 1-chloro-3-hydroxy-5,5-dimethylcyclohexene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-chloro-3-hydroxy-5,5-dimethylcyclohexene

There total 1 articles about 1-chloro-3-hydroxy-5,5-dimethylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-chloro-5,5-dimethylcyclohex-2-en-1-one (17530-69-7) → 1-chloro-3-hydroxy-5,5-dimethylcyclohexene (76181-36-7)

Guidance literature:

With aluminum isopropoxide; In isopropyl alcohol; for 22h; distilled;

Reference yield: 72.0%

1-chloro-3-hydroxy-5,5-dimethylcyclohexene (76181-36-7) → 1,3-dichloro-5,5-dimethylcyclohexene (76181-37-8)

Guidance literature:

With dichlorotriphenyl-λ⁴-phosphane; In acetonitrile; for 2.5h; Ambient temperature;

Reference yield:

1-chloro-3-hydroxy-5,5-dimethylcyclohexene (76181-36-7) → 1-(5',5'-dimethylcyclohex-1'-enyl)ethanone (57738-06-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / Ph₃PCl₂ / acetonitrile / 2.5 h / Ambient temperature

2: 79 percent / LiAlH₄ / diethyl ether / 17.5 h / Heating

3: 69 percent / Na

4: 10 percent / AlCl₃ / CH₂Cl₂ / 6.25 h / 0 °C

With lithium aluminium tetrahydride; aluminium trichloride; sodium; dichlorotriphenyl-λ⁴-phosphane; In diethyl ether; dichloromethane; acetonitrile;

upstream raw materials:

3-chloro-5,5-dimethylcyclohex-2-en-1-one

Downstream raw materials:

1,3-dichloro-5,5-dimethylcyclohexene

1-(3,3-dimethyl-cyclohexyl)-ethanone

3-acetyl-5,5-dimethylcyclohexene

1-(5',5'-dimethylcyclohex-1'-enyl)ethanone

Refernces

• 1、 Fleming, Ian,Pearce, Andrew. "Friedel-Crafts Reactions of Some Vinyisilanes". . p. 2485 - 2489. Retrieved 2007/10/02.