Chemical Property of Divaricoside
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Chemical Property:
- Vapor Pressure:2.05E-22mmHg at 25°C
- Boiling Point:696.1 °C at 760 mmHg
- Flash Point:223.4 °C
- PSA：114.68000
- Density:1.27 g/cm3
- LogP:3.11020
- XLogP3:1.9
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:4
- Exact Mass:534.31926842
- Heavy Atom Count:38
- Complexity:968
- Purity/Quality:
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98%min *data from raw suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3C(CC5(C4(CCC5C6=CC(=O)OC6)O)C)O)C)OC)O
- Isomeric SMILES:C[C@H]1[C@@H]([C@H](C[C@@H](O1)O[C@H]2CC[C@]3([C@@H](C2)CC[C@@H]4[C@@H]3[C@@H](C[C@]5([C@@]4(CC[C@@H]5C6=CC(=O)OC6)O)C)O)C)OC)O
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Description
Divasidum is a cardiac glycoside compound found in the seeds of Apocynaceae
plant Strophanthus divaricatus. Strophanthus divaricatus is also known as
Gelsemium elegans and Morinda umbellata L. This plant was recorded in Flora of
China . “Bencaoqiuyuan” suggested that it can be used for treating itching and
tinea capitis. “Lu Chuan Materia Medica” and “Lingnan herbal medicine” also suggest that it is useful for treating sore, congestion, malignant ulcers, and bruises. It
grows in Guizhou, Yunnan, Guangxi, Guangdong, and Fujian provinces in China. It
is also distributed in Vietnam and Laos. Divasidum, decogenin, sarmentogenin, sarmutogenin, bipindogenin, and other types of cardiac glycosides are found in the
roots, stems, leaves, and other parts of Strophanthus divaricatus. In China, divasidum has been developed into injection for the treatment of heart failure.
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Physical properties
Appearance: small white crystalline powder, odorless, bitter taste. Solubility: soluble in water, chloroform, or ether.
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Indications
This product is included in the Pharmacopoeia of the People’s Republic of China
(1963).
Divasidum injection can treat congestive heart failure and myocardial
infarction.
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Clinical Use
It was observed that among the 22 patients with congestive heart failure, divasidum
treatment displayed good therapeutic effect in 14 patients. In another report, divasidum treatment of congestive heart failure in 58 cases, 39 cases have good results.
However, fast injection induces side effects . The current clinical application of
the divasidum preparation is divasidum injection, which is a mixture of divasidum
and divostroside.
