1H-PYRAZOL-4-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: 1H-PYRAZOL-4-AMINE HYDROCHLORIDE
• CAS No.: 4331-28-6
• Molecular Formula: C3H6ClN3
• Molecular Weight: 119.554
• Hs Code.: 2933199090
• Mol file: 4331-28-6.mol

Synonyms:1H-Pyrazol-4-amine,monohydrochloride (9CI);Pyrazole, 4-amino-, hydrochloride (7CI,8CI);

Chemical Property of 1H-PYRAZOL-4-AMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000127mmHg at 25°C
• Boiling Point: 334.5 °C at 760 mmHg
• Flash Point: 182.6 °C
• PSA: 54.70000
• LogP: 1.37510
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H-Pyrazol-4-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-PYRAZOL-4-AMINE HYDROCHLORIDE

There total 1 articles about 1H-PYRAZOL-4-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-1H-pyrazole (2075-46-9) → 3-chloro-1H-pyrazole-4-amine hydrochloride (63680-90-0) + 1H-pyrazol-4-ylamine hydrochloride (4331-28-6,103286-58-4)

Guidance literature:

With hydrogenchloride; triethylsilane; Pd/Al₂O₃; In ethanol; water; at 15 ℃; for 73h; Overall yield = 99 %; Overall yield = 65.5 g; Inert atmosphere;

Reference yield: 88.0%

1H-pyrazol-4-ylamine hydrochloride (4331-28-6,103286-58-4) + (S)-2-(methylcarbamoyl)-6-(1-phenylethyl)isonicotinic acid → (S)-N2-methyl-6-(1-phenylethyl)-N4-(1H-pyrazol-4-yl)pyridine-2,4-dicarboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 64.0%

1H-pyrazol-4-ylamine hydrochloride (4331-28-6,103286-58-4) + 2-benzyl-6-(methylcarbamoyl)isonicotinic acid → 6-benzyl-N2-methyl-N4-(1H-pyrazol-4-yl)pyridine-2,4-dicarboxamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

upstream raw materials:

4-nitro-1H-pyrazole

Refernces