Hytrin

Base Information

• Chemical Name: Hytrin
• CAS No.: 70024-40-7
• Molecular Formula: C₁₉H₂₅N₅O₄*ClH*H₂O
• Molecular Weight: 441.915
• Hs Code.: 2934990002
• ChEMBL ID: CHEMBL1201091
• Mol file: 70024-40-7.mol

Synonyms:Hytrin;Terazosin HCl;Terasin;MLS000758297;SCHEMBL8540346;CHEMBL1201091;CCG-100778;NC00028;SMR000449268

Chemical Property of Hytrin

Chemical Property:

• Appearance/Colour: white or off-white crystalline powder
• Vapor Pressure: 1.59E-17mmHg at 25°C
• Melting Point: 271-274 °C
• Boiling Point: 664.5 °C at 760 mmHg
• Flash Point: 355.7 °C
• PSA: 121.50000
• LogP: 2.31430
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent), practically insoluble in acetone.
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 441.1778967
• Heavy Atom Count: 30
• Complexity: 544

Purity/Quality:

99% ^*data from raw suppliers

Terazosin Hydrochloride Dihydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.O.Cl
• Uses: Terazosin Hydrochloride Dihydrate is an α-1-adrenergic blocker related to prazosin.
• Therapeutic Function: Antihypertensive

Technology Process of Hytrin

There total 4 articles about Hytrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) + N-(tetrahydro-2-furoyl)-piperazine (63074-07-7) → 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate (70024-40-7)

Guidance literature:

In 1,4-dioxane; water;

Reference yield:

isopropyl alcohol (67-63-0,8013-70-5) + 2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) + N-(tetrahydro-2-furoyl)-piperazine (63074-07-7) → 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate (70024-40-7)

Guidance literature:

In water;

Reference yield:

→ 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate (70024-40-7)

Guidance literature:

upstream raw materials:

isopropyl alcohol

2-chloro-6,7-dimethoxyquinazolin-4-amine

N-(tetrahydro-2-furoyl)-piperazine

Refernces

• 1、 -. "Process for the preparation of terazosin hydrochloride dihydrate". . . Retrieved 2008/06/13.
• 2、 -. "Terazosin crystalline polymorph and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.