Indole-3-carboxaldehyde azine

Base Information

• Chemical Name: Indole-3-carboxaldehyde azine
• CAS No.: 1233-49-4
• Molecular Formula: C₁₈H₁₄N₄
• Molecular Weight: 286.336
• Hs Code.: 2933990090
• European Community (EC) Number: 654-638-5
• DSSTox Substance ID: DTXSID50924444
• ChEMBL ID: CHEMBL1906165
• Mol file: 1233-49-4.mol

Synonyms:1,4-bis(3-indolyl)-2,3-diaza-1,3-butadiene

Chemical Property of Indole-3-carboxaldehyde azine

Chemical Property:

• Vapor Pressure: 3.85E-08mmHg at 25°C
• Boiling Point: 445.8°Cat760mmHg
• Flash Point: 223.4°C
• PSA: 56.30000
• Density: 1.26g/cm³
• LogP: 4.10220
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 286.121846464
• Heavy Atom Count: 22
• Complexity: 393

Purity/Quality:

98%min ^*data from raw suppliers

(2,2')BIINDENYL-1,3,1',3'-TETRAONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C=NN=CC3=CNC4=CC=CC=C43

Technology Process of Indole-3-carboxaldehyde azine

There total 4 articles about Indole-3-carboxaldehyde azine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Indole-3-carboxaldehyde hydrazone (83710-36-5) → Indole-3-carboxaldehyde azine (1233-49-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.0833333h;

DOI:10.1021/je00031a035

Reference yield: 79.6%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → Indole-3-carboxaldehyde azine (1233-49-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1039/b821466b

Reference yield:

indol-3-ylmethylene-hydrazinecarboxylic acid ethyl ester (15641-27-7) → Indole-3-carboxaldehyde azine (1233-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 5 h / Heating

2: 91 percent / 6 N aq. HCl / ethanol / 0.08 h

With hydrogenchloride; hydrazine hydrate; In ethanol;

DOI:10.1021/je00031a035

upstream raw materials:

Indole-3-carboxaldehyde

Indole-3-carboxaldehyde hydrazone

indol-3-ylmethylene-hydrazinecarboxylic acid ethyl ester

Refernces

• 1、 El-Rayyes, Nizar R.,Katrib, Ali H.. "Synthesis and X-ray Photoelectron Spectra of Some Azines". . p. 132 - 134. Retrieved 2007/10/02.