α-Hydroxy-3-nitrobenzeneacetic acid

Base Information

• Chemical Name: α-Hydroxy-3-nitrobenzeneacetic acid
• CAS No.: 42164-79-4
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.147
• Mol file: 42164-79-4.mol

Synonyms:3-nitro-mandelic acid;(R,S)3-nitromandelic acid;m-nitromandelic acid;D-3-nitro-mandelic acid;3-nitro-DL-mandelic acid;3-Nitro-DL-mandelsaeure;

Chemical Property of α-Hydroxy-3-nitrobenzeneacetic acid

Chemical Property:

• Vapor Pressure: 2.7E-07mmHg at 25°C
• Boiling Point: 405.3°C at 760 mmHg
• Flash Point: 183.1°C
• PSA: 103.35000
• Density: 1.552g/cm³
• LogP: 1.23600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

2-hydroxy-2-(3-nitrophenyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-Hydroxy-3-nitrobenzeneacetic acid

There total 17 articles about α-Hydroxy-3-nitrobenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trimethylsilyl cyanide (7677-24-9) + 3-nitro-benzaldehyde (99-61-6) → 3-nitromandelic acid (42164-79-4)

Guidance literature:

trimethylsilyl cyanide; 3-nitro-benzaldehyde; With zinc(II) iodide; In dichloromethane; at 0 - 25 ℃;

With hydrogenchloride; In water; at 100 ℃;

DOI:10.1016/S0040-4039(03)01270-X

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + benzoyloxy-(3-nitro-phenyl)-acetic acid anilide → 3-nitromandelic acid (42164-79-4) + aniline (62-53-3) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

Reference yield:

2-(3-nitrophenyl)-2-[(trimethylsilyl)oxy]acetonitrile (93555-01-2) → 3-nitromandelic acid (42164-79-4)

Guidance literature:

With hydrogenchloride; In water; for 3h; Heating / reflux;

upstream raw materials:

3-nitrophenylglyoxal

2,2-dibromo-1-(3-nitrophenyl)ethan-1-one

3-nitro-mandelonitrile

meta nitromandelic acid ethyl ester

Downstream raw materials:

(R,S)-2-hydroxy-2-(3-aminophenyl)acetic acid

(R)-(-)-3-nitromandelic acid

(S)-Acetoxy-(3-nitro-phenyl)-acetic acid

2-(3-nitrophenyl)-4,5-diphenyl-1H-imidazole

Refernces

• 1、 -. "7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids". . . Retrieved 2008/06/13.
• 2、 -. "7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids". . . Retrieved 2008/06/13.