7,8-dihydroxyquinoline

Base Information

• Chemical Name: 7,8-dihydroxyquinoline
• CAS No.: 101724-22-5
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Mol file: 101724-22-5.mol

Synonyms:7,8-dihydroxyquinoline

Chemical Property of 7,8-dihydroxyquinoline

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

7,8-Dihydroxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,8-dihydroxyquinoline

There total 9 articles about 7,8-dihydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

8-quinolinol (148-24-3,24804-14-6) → 7,8-dihydroxyquinoline (101724-22-5)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; chloroform; at -25 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.03.060

Reference yield:

2-nitroveratraldehyde (55149-84-3) → 7,8-dihydroxyquinoline (101724-22-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Raney nickel; ethyl acetate / Hydrogenation

2: sodium ethylate; ethanol

3: pyridine hydrochloride / 200 - 220 °C

With ethanol; sodium ethanolate; pyridine hydrochloride; nickel; ethyl acetate;

Reference yield:

sodium 8-quinolinolate (2872-54-0) → 7,8-dihydroxyquinoline (101724-22-5)

Guidance literature:

With [((2-pyridyl)bis(3-tert-butylpyrazol-2-yl)methane)Cu₂O₂](SbF₆)₂; In tetrahydrofuran; dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1002/anie.201301249

upstream raw materials:

7,8-dimethoxy-quinoline-2-carboxylic acid

8-quinolinol

2-nitroveratraldehyde

2-nitrovanillin

Refernces

• 1、 Hoffmann, Alexander,Citek, Cooper,Binder, Stephan,Goos, Arne,Ruebhausen, Michael,Troeppner, Oliver,Ivanovic-Burmazovic, Ivana,Wasinger, Erik C.,Stack, T. Daniel P.,Herres-Pawlis, Sonja. "Catalytic phenol hydroxylation with dioxygen: Extension of the tyrosinase mechanism beyond the protein matrix". . p. 5398 - 5401. Retrieved 2013.