Fonturacetam

Base Information

• Chemical Name: Fonturacetam
• CAS No.: 77472-70-9
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.255
• Hs Code.: 2933990090
• European Community (EC) Number: 688-268-0
• UNII: 99QW5JU66Y
• DSSTox Substance ID: DTXSID30868438
• Nikkaji Number: J125.978D
• Wikipedia: Phenylpiracetam
• Wikidata: Q420882
• NCI Thesaurus Code: C96852
• ChEMBL ID: CHEMBL348639
• Mol file: 77472-70-9.mol

Synonyms:4-phenylpiracetam;phenotropil

Chemical Property of Fonturacetam

Chemical Property:

• Vapor Pressure: 1.3E-09mmHg at 25°C
• Melting Point: 129.5-130.5 °C(Solv: ethyl acetate (141-78-6))
• Refractive Index: 1.579
• Boiling Point: 486.4 °C at 760 mmHg
• PKA: 15.67±0.40(Predicted)
• Flash Point: 247.9 °C
• PSA: 64.39000
• Density: 1.22 g/cm³
• LogP: 1.57540
• Storage Temp.: Refrigerator
• Solubility.: Acetonitrile (Slightly), Chloroform, DMSO (Slightly), Methanol (Sparingly, Sonic
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 218.105527694
• Heavy Atom Count: 16
• Complexity: 285

Purity/Quality:

99% ^*data from raw suppliers

Carphedone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CN(C1=O)CC(=O)N)C2=CC=CC=C2
• Description: 4-Phenyl-2-pyrrolidone-1-acetamide (also named as Phenylpiracetam, Fonturacetam) is a phenylated analog of the drug piracetam, which was developed in 1983 in Russia. It is now available as a prescription drug. It has antiamnesic, anticonvulsant and anxiolytic properties. It is used as a general stimulant or to increase tolerance to extreme temperatures and stress.
• Uses: Carphedone is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide were studied. Carphedone is a GABA derivative that exhibited apparent immunocorrection properties during immunosuppression induced by cyclophosphamide.

Technology Process of Fonturacetam

There total 13 articles about Fonturacetam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester (70291-40-6) → (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide (77472-70-9)

Guidance literature:

With ammonia; In methanol; at 45 - 50 ℃; for 5h;

DOI:10.1007/BF00765621

Reference yield: 97.0%

4-[(2-amino-2-oxoethyl)amino]-3-phenylbutanoic acid → (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide (77472-70-9)

Guidance literature:

Heating;

DOI:10.1134/S1070428017060100

Reference yield: 81.0%

methyl-2-oxo-4-phenylpyrrolidine-1-acetate (68497-63-2) → (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide (77472-70-9)

Guidance literature:

With ammonium hydroxide; for 2h;

upstream raw materials:

methyl-2-oxo-4-phenylpyrrolidine-1-acetate

2-oxo-4-phenyl-1-pyrrolidineacetic acid, ethyl ester

4-phenylpyrrolidin-2-one

4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone

Downstream raw materials:

C₃₄H₄₄N₂O₃

Refernces

• 1、 -. "Method for preparing phenyl piracetam". Paragraph 0075; 0076; 0077; 0078; 0079; 0080-0088. . Retrieved 2017/05/09.
• 2、 Glozman, O. M.,Morozov, I. S.,Zhmurenko, L. A.,Zagorevskii, V. A.. "THE SYNTHESIS AND ANTISPASMODIC ACTIVITY OF 4-PHENYLPYRROLIDONE-2-ACETAMIDES". . p. 776 - 780. Retrieved 2007/10/02.