2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties

Base Information

• Chemical Name: 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties
• CAS No.: 97799-98-9
• Molecular Formula: C₆H₆ClNOS
• Molecular Weight: 175.639
• Mol file: 97799-98-9.mol

Synonyms:5-chloro-2-thiophenecarboxylic acid N-methylamide

Chemical Property of 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties

Chemical Property:

• Melting Point: 164-166°C
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-N-methylthiophene-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Chloro-N-methylthiophene-2-carboxamide is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Technology Process of 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties

There total 1 articles about 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C6H6ClNOS (42520-87-6) → N-(5-chloro-2-thienyl)acetamide (42152-55-6) + 5-chloro-2-thiophenecarboxylic acid N-methylamide (97799-98-9)

Guidance literature:

With phosphorus pentachloride; Overall yield = 30 %;

DOI:10.1021/jm400676g

Reference yield: 72.0%

5-chloro-2-thiophenecarboxylic acid N-methylamide (97799-98-9) + (allylsulfonyl)benzene (16212-05-8) → (E)-5-chloro-N-methyl-3-(3-(phenylsulfonyl)prop-1-en-1-yl)thiophene-2-carboxamide

Guidance literature:

With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; copper(II) acetate monohydrate; acetic acid; In 1,4-dioxane; at 20 - 110 ℃; for 24h; stereoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.1c02424

Reference yield:

5-chloro-2-thiophenecarboxylic acid N-methylamide (97799-98-9) → 5-Chlorothiophene-2-carboxylic acid (24065-33-6)

Guidance literature:

With water;

DOI:10.1007/BF00504398

upstream raw materials:

C₆H₆ClNOS

Downstream raw materials:

5-Chlorothiophene-2-carboxylic acid

Refernces