Technology Process of Sparsomycin
There total 14 articles about Sparsomycin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dowex(R) 50W H(1+) form;
In
methanol;
at 50 ℃;
for 2h;
DOI:10.1271/bbb.67.2556
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 88 percent / dicyclohexyl carbodiimide; 1-hydroxy-7-azabenzotriazole / dimethylformamide / 12 h / 20 °C
2: 74 percent / Dowex(R) 50W H(1+) form / methanol / 2 h / 50 °C
With
1-hydroxy-7-aza-benzotriazole; Dowex(R) 50W H(1+) form; dicyclohexyl-carbodiimide;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1271/bbb.67.2556
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 60 percent / ceric ammonium nitrate / H2O / 25 °C
2: 75 percent / dimethylsulfoxide / 50 h / 25 °C
3: 90 percent / 3 N aq. NaOH / methanol; dioxane / 24 h / 25 °C
4: 1.) triethylamine / 1.) DMF, THF, 0 deg C, 5 min, 2.) RT, 4 h
5: tetrahydrofuran; dimethylformamide / 36 h / Ambient temperature
6: 65 percent / 1 N HCl / methanol / 5 h / 50 °C
With
hydrogenchloride; sodium hydroxide; ammonium cerium(IV) nitrate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00208a022
T+
