Flurazepam

Base Information

• Chemical Name: Flurazepam
• CAS No.: 17617-23-1
• Molecular Formula: C21H23 Cl F N3 O
• Molecular Weight: 387.885
• European Community (EC) Number: 241-591-7
• UNII: IHP475989U
• DSSTox Substance ID: DTXSID1023071
• Nikkaji Number: J3.142I
• Wikipedia: Flurazepam
• Wikidata: Q418998
• NCI Thesaurus Code: C62030
• RXCUI: 4501
• Pharos Ligand ID: ZSQAYCGU3ZLQ
• Metabolomics Workbench ID: 43003
• ChEMBL ID: CHEMBL968
• Mol file: 17617-23-1.mol

Synonyms:Apo Flurazepam;Apo-Flurazepam;Dalmadorm;Dalmane;Dihydrochloride, Flurazepam;Dormodor;Flurazepam;Flurazepam Dihydrochloride;Flurazepam Hydrochloride;Flurazepam Mono Perchlorate;Flurazepam Mono-Perchlorate;Flurazepam Monohydrochloride;Hydrochloride, Flurazepam;Mono-Perchlorate, Flurazepam;Monohydrochloride, Flurazepam;Staurodorm

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Flurazepam

Chemical Property:

• Vapor Pressure: 3.34E-12mmHg at 25°C
• Melting Point: 77-82°
• Boiling Point: 551.4°Cat760mmHg
• PKA: pKa 1.90±0.05(H2O) (Uncertain);8.16±0.05 (Uncertain)
• Flash Point: 287.2°C
• PSA: 35.91000
• Density: 1.21g/cm³
• LogP: 3.50550
• Storage Temp.: 2-8°C
• Solubility.: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 387.1513682
• Heavy Atom Count: 27
• Complexity: 540

Purity/Quality:

Safty Information:

• Hazard Codes: Xn,T,F
• Statements: 22-33-39/23/24/25-23/24/25-11
• Safety Statements: 1/2-22-36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Sedatives and Hypnotics
• Canonical SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F
• Recent ClinicalTrials: Study to Evaluate the Effect of 2 Dosage Strengths of Lemborexant (E2006) on a Multiple Sleep Latency Test in Participants With Insomnia Disorder
• Description: Flurazepam (CRM) (Item No. 18160) is a certified reference material that is structurally categorized as a benzodiazepine. It acts as a partial agonist of the benzodiazepine site on GABAA receptors, potentiating the action of GABA with an EC50 value of 930 nM in neuronal chick spinal cord cultures. Through this signaling mechanism, flurazepam produces anxiolytic and sedative properties that have been implemented clinically in the treatment of insomnia but also carry a potential for misuse. This product is intended for forensic and research purposes.
• Uses: Anticonvulsant; relaxant (muscle); sedative-hypnotic Dalmane (Valeant.
• Therapeutic Function: Hypnotic

Technology Process of Flurazepam

There total 1 articles about Flurazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ flurazepam (17617-23-1)

Guidance literature:

DOI:10.1021/jm00330a019

Reference yield: 92.0%

3,5-dimethylphenyl iodide (22445-41-6) + flurazepam (17617-23-1) → C29H31ClFN3O

Guidance literature:

With C₁₇H₂₄N₅Ru⁽¹⁺⁾*F₆P^(1-); potassium acetate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 48h; Inert atmosphere;

DOI:10.1038/s41557-018-0062-3

Reference yield:

flurazepam (17617-23-1) → 2-amino-5-chloro-2'-fluorobenzophenone (784-38-3) + 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one (2886-65-9)

Guidance literature:

With hydrogenchloride; multistep reaction: biotransformation, acid hydrolysis;

Downstream raw materials:

2-amino-5-chloro-2'-fluorobenzophenone

7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2(2H)-one

Refernces