TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID
• CAS No.: 3685-25-4
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Hs Code.: 29159000
• Mol file: 3685-25-4.mol

Synonyms:4-Aminocyclohexanecarboxylic acid;4-Amino cyclohexane-l-carboxylic acid;Cyclohexanecarboxylic acid, 4-amino-;

Chemical Property of TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Melting Point: 495 °C
• Boiling Point: 280 °C at 760 mmHg
• PKA: 4.46±0.10(Predicted)
• Flash Point: 123.1 °C
• PSA: 63.32000
• Density: 1.133 g/cm³
• LogP: 1.28880
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-4-Aminocyclohexanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID

There total 11 articles about TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-tert-butylsulfinamidocyclohexanecarboxylic acid → trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield: 49.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7) + cis-4-aminocyclohexane-1-carboxylic acid (3685-23-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; water; at 20 ℃; under 2689.17 Torr;

DOI:10.1016/S0223-5234(00)01206-X

Reference yield:

→ trans-4-aminocyclohexanecarboxylic acid (1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7)

Guidance literature:

With hydrogenchloride; at 170 ℃;

upstream raw materials:

4-amino-benzoic acid

ethyl 4-(hydroxyimino)cyclohexane-1-carboxylate

4-hydroxyimino-cyclohexanecarboxylic acid

4-oxocyclohexanecarboxylic acid tert-butyl ester

Downstream raw materials:

trans-4-(fluorenylmethoxycarbonylamino)cyclohexanecarboxylic acid

trans-4-(trifluoroacetamido)cyclohexanecarboxylic acid

trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF TRANS-4-AMINO-1-CYCLOHEXANECARBOXILIC ACID AND ITS DERIVATIVES". Page/Page column 10. . Retrieved 2017/09/02.
• 2、 -. "NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS". . . Retrieved 2010/08/07.