Abamectin B1a

Base Information Edit

Chemical Name:Abamectin B1a
CAS No.:65195-55-3
Molecular Formula:C48H72O14
Molecular Weight:873.091
Hs Code.:2932999099
European Community (EC) Number:265-610-3
UNII:K54ZMM929K
DSSTox Substance ID:DTXSID9058238
Wikidata:Q44107971
Metabolomics Workbench ID:54082
ChEMBL ID:CHEMBL1630577
Mol file:65195-55-3.mol

Synonyms:5-O-demethylavermectin A1a;avermectin B(1)a;avermectin B1a;C 076;C-076

Suppliers and Price of Abamectin B1a

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Avermectin B1a
1mg
$ 503.00

TRC
AbamectinB1a
25mg
$ 1100.00

Matrix Scientific
Avermectin B1A
5g
$ 1134.00

Matrix Scientific
Avermectin B1A
10g
$ 1816.00

Matrix Scientific
Avermectin B1A
1g
$ 324.00

Crysdot
AvermectinB1a 98+%
1g
$ 750.00

Crysdot
AvermectinB1a 98+%
100mg
$ 180.00

Crysdot
AvermectinB1a 98+%
50mg
$ 110.00

Crysdot
AvermectinB1a 98+%
25mg
$ 70.00

Crysdot
AvermectinB1a 98+%
250mg
$ 320.00

Total 81 raw suppliers

Chemical Property of Abamectin B1a Edit

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:0mmHg at 25°C
Melting Point:157-162oC
Refractive Index:1.571
Boiling Point:940.912 °C at 760 mmHg
PKA:12.42±0.70(Predicted)
Flash Point:268.073 °C
PSA：170.06000
Density:1.244 g/cm³
LogP:5.37740
Solubility.:≥143.4 mg/mL in DMSO; ≥11.86 mg/mL in EtOH with ultrasonic; insoluble in H2O
XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:8
Exact Mass:872.49220697
Heavy Atom Count:62
Complexity:1730

Purity/Quality:

99% ^*data from raw suppliers

Avermectin B1a ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCC(C)C1C(C=CC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
Isomeric SMILES:CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
Description Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent that binds to high and low affinity sites on the mammalian GABAA receptor. Binding to the high affinity site activates the receptor to increase chloride influx, while binding to the low affinity site blocks the channel. Avermectin B1a inhibits binding of the glycine receptor antagonist strychnine to membranes and the solubilized receptor from rat spinal cord (Kis = 1.3 and 3.6 μM, respectively). Formulations containing avermectin B1a (>80%) and avermectin B1b (~20%; ) are used in insecticides and veterinary anthelmintic formulas as abamectin .
Uses Avermectin B1a is the major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1a contains a secbutyl residue in the 25-position. In vitro and in vivo studies have shown that this analogue is the more potent analogue in the commercial product.
Therapeutic Function Antiparasitic

Technology Process of Abamectin B1a

There total 119 articles about Abamectin B1a which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%